Abstract
We enrolled 196 patients with hypertension who were already being treated with free-drug combinations of angiotensin-II receptor blocker (ARB) and amlodipine. The free-drug combinations of ARB and amlodipine were replaced with the same dose of the fixed-dose combinations. The average home blood pressure (BP) in all patients receiving fixed-dose combinations was significantly lower than those receiving free-drug combinations (131 ± 10/75 ± 8 vs. 136 ± 11/77 ± 9 mm Hg, P < .01) accompanied with increasing drug adherence. After lowering BP by fixed-dose combinations, the costs for medications decreased by 31% over the 3 months.
Publication types
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Multicenter Study
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Observational Study
MeSH terms
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Aged
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Aged, 80 and over
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Amlodipine / economics
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Amlodipine / pharmacology
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Amlodipine / therapeutic use*
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Angiotensin Receptor Antagonists / economics
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Angiotensin Receptor Antagonists / pharmacology
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Angiotensin Receptor Antagonists / therapeutic use*
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Benzimidazoles / economics
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Benzimidazoles / pharmacology
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Benzimidazoles / therapeutic use
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Benzoates / economics
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Benzoates / pharmacology
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Benzoates / therapeutic use
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Biphenyl Compounds
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Blood Pressure Monitoring, Ambulatory
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Calcium Channel Blockers / economics
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Calcium Channel Blockers / pharmacology
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Calcium Channel Blockers / therapeutic use*
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Female
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Health Care Costs / statistics & numerical data*
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Humans
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Hypertension / drug therapy*
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Hypertension / economics*
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Hypertension / physiopathology
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Male
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Medication Adherence*
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Middle Aged
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Prospective Studies
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Retrospective Studies
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Telmisartan
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Tetrazoles / economics
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Tetrazoles / pharmacology
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Tetrazoles / therapeutic use
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Treatment Outcome
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Valine / analogs & derivatives
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Valine / economics
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Valine / pharmacology
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Valine / therapeutic use
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Valsartan
Substances
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Angiotensin Receptor Antagonists
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Benzimidazoles
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Benzoates
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Biphenyl Compounds
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Calcium Channel Blockers
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Tetrazoles
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Amlodipine
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Valsartan
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Valine
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candesartan
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Telmisartan