Synergistic activity of chloroquine with fluconazole against fluconazole-resistant isolates of Candida species

Yali Li; Zhe Wan; Wei Liu; Ruoyu Li

doi:10.1128/AAC.04417-14

Synergistic activity of chloroquine with fluconazole against fluconazole-resistant isolates of Candida species

Antimicrob Agents Chemother. 2015 Feb;59(2):1365-9. doi: 10.1128/AAC.04417-14. Epub 2014 Dec 15.

Authors

Yali Li¹, Zhe Wan¹, Wei Liu², Ruoyu Li¹

Affiliations

¹ Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
² Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China [email protected].

Abstract

The in vitro activity of chloroquine and the interactions of chloroquine combined with fluconazole against 37 Candida isolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests. Synergistic effect was detected with 6 of 9 fluconazole-resistant Candida albicans isolates, with Candida krusei ATCC 6258, and with all 12 fluconazole-resistant Candida tropicalis isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents
Candida / drug effects*
Chloroquine / pharmacology*
Drug Resistance, Fungal
Drug Synergism
Fluconazole / pharmacology*
Microbial Sensitivity Tests

Substances

Antifungal Agents
Chloroquine
Fluconazole