A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19

Zohreh Esam

doi:10.1016/j.diabres.2020.108282

A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19

Diabetes Res Clin Pract. 2020 Sep:167:108282. doi: 10.1016/j.diabres.2020.108282. Epub 2020 Jun 25.

Author

Zohreh Esam¹

Affiliation

¹ Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. Electronic address: [email protected].

Abstract

The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19.

Keywords: COVID-19; Metformin; SARS-CoV-2; V-ATPase; eNHEs.

Publication types

Letter
Comment

MeSH terms

Betacoronavirus*
COVID-19
COVID-19 Drug Treatment
Coronavirus Infections* / drug therapy
Humans
Metformin*
Pandemics*
Pneumonia, Viral*
SARS-CoV-2

Substances

Metformin