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MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data

Wellcome Open Res. 2020 Dec 10:5:252. doi: 10.12688/wellcomeopenres.16374.2. eCollection 2020.

Abstract

The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or updated in recent years. These features can be divided into four categories: robust methods for Mendelian randomization, methods for multivariable Mendelian randomization, functions for data visualization, and the ability to load data into the package seamlessly from the PhenoScanner web-resource. We provide examples of the graphical output produced by the data visualization commands, as well as syntax for obtaining suitable data and performing a Mendelian randomization analysis in a single line of code.

Keywords: Mendelian randomization; causal inference; genetic associations.; genetic epidemiology; instrumental variable; post-GWAS analysis; summarized data.