Abstract
The Cucumber mosaic virus (CMV) is an isodiametric plant virus with an extremely wide host range, present worldwide. CMV chimeric particles (R9-CMV), engineered to express a 27-aa synthetic peptide derived from Hepatitis C virus (HCV), were demonstrated to be stable under simulated gastric and intestinal conditions. Then the possibility of inducing a humoral immune response in rabbits fed with R9-CMV infected lettuce plants was demonstrated, suggesting that this system could function as a confirming tool of a bioreactor for the production of a stable edible vaccine against HCV.
Copyright 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Amino Acid Sequence
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Animals
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Cucumovirus / chemistry*
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Cucumovirus / genetics
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Epitopes / administration & dosage
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Epitopes / chemistry
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Epitopes / immunology
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Hepacivirus / chemistry*
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Hepacivirus / genetics
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Hepacivirus / immunology
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Hepatitis C / prevention & control*
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Hepatitis C Antibodies / blood
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Intestines
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Nanoparticles / chemistry*
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Peptides / administration & dosage
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Peptides / chemical synthesis
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Peptides / immunology
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Rabbits
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Reassortant Viruses / chemistry
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Reassortant Viruses / genetics
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Reassortant Viruses / immunology
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Stomach
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Vaccines, Edible / administration & dosage
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Vaccines, Edible / chemistry
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Vaccines, Edible / immunology
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Viral Hepatitis Vaccines / administration & dosage
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Viral Hepatitis Vaccines / chemistry*
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Viral Hepatitis Vaccines / immunology
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Virion / immunology
Substances
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Epitopes
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Hepatitis C Antibodies
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Peptides
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Vaccines, Edible
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Viral Hepatitis Vaccines