Abstract
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
MeSH terms
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Animals
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Cell Line
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DNA, Viral / genetics
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Electrophoresis, Polyacrylamide Gel
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Gene Expression Regulation, Viral*
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / immunology*
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Humans
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Interleukin-10
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Interleukins / biosynthesis*
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Killer Cells, Natural / immunology
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Mice
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Radioimmunoprecipitation Assay
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T-Lymphocytes / immunology
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Viral Proteins / genetics
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Viral Proteins / immunology*
Substances
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BCRF1 protein, Human herpesvirus 4
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DNA, Viral
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Interleukins
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Viral Proteins
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Interleukin-10