A Case of Adult Intestinal Toxemia Botulism During Prolonged Hospitalization in an Allogeneic Hematopoietic Cell Transplant Recipient

Lalitha Parameswaran; Agam Rao; Katherine Chastain; Joel Ackelsburg; Eleanor Adams; Brendan Jackson; Louis P Voigt; Xi Chen; Farid Boulad; Ying Taur

doi:10.1093/cid/cix847

A Case of Adult Intestinal Toxemia Botulism During Prolonged Hospitalization in an Allogeneic Hematopoietic Cell Transplant Recipient

Clin Infect Dis. 2017 Dec 27;66(suppl_1):S99-S102. doi: 10.1093/cid/cix847.

Authors

Lalitha Parameswaran¹, Agam Rao², Katherine Chastain³, Joel Ackelsburg⁴, Eleanor Adams⁵, Brendan Jackson², Louis P Voigt⁶, Xi Chen^{7

8}, Farid Boulad^{3

8}, Ying Taur^{1

8

9}

Affiliations

¹ Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
² Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
³ Department of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York.
⁴ Bureau of Communicable Disease, New York City Department of Health and Mental Hygiene, New York.
⁵ New York State Department of Health, Albany.
⁶ Department of Medicine, Critical Care Medicine Service, New York.
⁷ Department of Neurology, Memorial Sloan Kettering Cancer Center, New York.
⁸ Weill Cornell Medical College, New York.
⁹ Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan-Kettering Cancer Center, New York, New York.

PMID: 29293935
DOI: 10.1093/cid/cix847

Abstract

We report a laboratory-confirmed case of adult intestinal toxemia botulism in an allogeneic hematopoietic stem cell transplantation (allo-HCT) recipient. Onset of symptoms occurred within the hospitalized setting, making this case particularly unique. Botulism may have arisen because of significant intestinal disruption and compromise, and not directly from immune compromise.

Keywords: 16S rRNA gene sequencing; adult intestinal toxemia botulism; bone marrow transplant; botulism; microbiota.

Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Publication types

Case Reports

MeSH terms

Adult
Botulism / complications*
Clostridium botulinum / isolation & purification
Hematopoietic Stem Cell Transplantation*
Humans
Intestines / microbiology
Length of Stay
Male
Postoperative Complications / microbiology*
Toxemia / microbiology*
Transplantation, Homologous