Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

Mona O Mohsen; Ariane C Gomes; Monique Vogel; Martin F Bachmann

doi:10.3390/vaccines6030037

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

Vaccines (Basel). 2018 Jul 2;6(3):37. doi: 10.3390/vaccines6030037.

Authors

Mona O Mohsen^{1

2

3}, Ariane C Gomes⁴, Monique Vogel⁵, Martin F Bachmann^{6

7}

Affiliations

¹ Jenner Institute, University of Oxford, Oxford OX3 7BN, UK. [email protected].
² Qatar Foundation, Doha, Qatar. [email protected].
³ Inselspital, Universitatsklinik RIA, Immunologie, 3010 Bern, Switzerland. [email protected].
⁴ Jenner Institute, University of Oxford, Oxford OX3 7BN, UK. [email protected].
⁵ Inselspital, Universitatsklinik RIA, Immunologie, 3010 Bern, Switzerland. [email protected].
⁶ Jenner Institute, University of Oxford, Oxford OX3 7BN, UK. [email protected].
⁷ Inselspital, Universitatsklinik RIA, Immunologie, 3010 Bern, Switzerland. [email protected].

Abstract

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.

Keywords: Toll-like receptor (TLR); adaptive immune system; innate immune system; virus-like particle (VLP).

Publication types

Review