Cadmium(Cd) is one of the most dangerous occupational and environmental toxins. The objective of ... more Cadmium(Cd) is one of the most dangerous occupational and environmental toxins. The objective of the present
study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats
intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal
diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking
water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum
calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were
decreased when compared with the control group, while PA-administered groups with Cd showed a significant
improvement when compared with the Cd-treated rats only. Serumthyroid stimulating hormone (TSH) level was
significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet
decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity
in rats.
Keywords
Cadmium, phytic acid, thyroid, T3, T4, TSH, toxicity
Cadmium(Cd) is one of the most dangerous occupational and environmental toxins. The objective of ... more Cadmium(Cd) is one of the most dangerous occupational and environmental toxins. The objective of the present
study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats
intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal
diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking
water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum
calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were
decreased when compared with the control group, while PA-administered groups with Cd showed a significant
improvement when compared with the Cd-treated rats only. Serumthyroid stimulating hormone (TSH) level was
significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet
decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity
in rats.
Keywords
Cadmium, phytic acid, thyroid, T3, T4, TSH, toxicity
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study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats
intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal
diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking
water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum
calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were
decreased when compared with the control group, while PA-administered groups with Cd showed a significant
improvement when compared with the Cd-treated rats only. Serumthyroid stimulating hormone (TSH) level was
significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet
decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity
in rats.
Keywords
Cadmium, phytic acid, thyroid, T3, T4, TSH, toxicity
study is to examine the potential prophylactic effects of phytic acid (PA) on thyroid hormones of male rats
intoxicated with Cd. The male albino rats were divided into five groups: group I (control) was fed with the basal
diet, group II was intoxicated with Cd in drinking water, groups III, IV, and V were intoxicated with Cd in drinking
water and fed with the diet containing 3.5, 7, and 10 g of PA/kg, respectively. The results indicated that the serum
calcium, iron (Fe), and total Fe binding capacity levels and serum T3 and T4 in Cd-treated rats of group II were
decreased when compared with the control group, while PA-administered groups with Cd showed a significant
improvement when compared with the Cd-treated rats only. Serumthyroid stimulating hormone (TSH) level was
significantly increased in Cd-treated rats compared with the control group, while the addition of PA in diet
decreased the high levels of TSH. These results indicated a prophylactic effect of PA against Cd-induced toxicity
in rats.
Keywords
Cadmium, phytic acid, thyroid, T3, T4, TSH, toxicity