Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its preva... more Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its prevalence is however probably underestimated in dermatological literature. Early recognition of the signs can prevent misdiagnosis. We describe a Turkish patient who presented with palmoplantar pustulosis and involvement of the sternoclavicular joint and peripheral oligoarthritis.
The association between chronic idiopathic urticaria (CIU) and thyroid autoimmunity has most ofte... more The association between chronic idiopathic urticaria (CIU) and thyroid autoimmunity has most often been suggested in studies investigating thyroid microsomal antibodies, which are less sensitive and specific than anti-thyroperoxidase antibodies, moreover these studies were not case-control studies in large series. By comparing a large patient series presenting with CIU with a large numbered control group we aimed to learn the extent of autoimmune thyroid disease. We compared the frequency of thyroid autoantibodies in 140 patients with CIU with 181 age-and sex-matched volunteers. Thyroid function tests and thyroid autoantibodies were measured by chemiluminescent immunometric assay in study groups. The frequency of thyroid autoantibodies was significantly higher in patients with CIU than that in healthy controls (29.28 %/5.52%; p < 0.001). Of 41 patients, 10 had thyroid dysfunction and the other cases were euthyroid. The higher frequency of these antibodies in our patients shows that there was a strong association between CIU and thyroid autoimmunity.
CD4+/CD56+ hematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm) involving the ski... more CD4+/CD56+ hematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm) involving the skin is relatively rare and has been of significant interest in the recent literature. We report here a 64-year-old male who presented with multiple purple-red nodules and plaques on his face, back, and chest. Histological examination of skin biopsies showed an intense hematolymphoid infiltration in the dermis and in the subcutaneous tissue. Stains were positive for CD4 (weak), CD56, and terminal deoxynucleotidyl transferase (TdT). These cells were negative for CD2, CD3, CD5, CD10, CD20, CD30, CD68, and T cell intracellular antigen (TIA). In situ hybridization (ISH) for Epstein-Barr virus was negative and the diagnosis was blastic NK cell lymphoma. The patient was treated with a hyper-CVAD regimen (cyclophosphamide, vincristine, doxorubicine, dexamethasone, methotrexate, and cytarabine).This treatment regimen achieved partial remission but the patient died eight months after the diagnosis. The patient presented with exclusively cutaneous involvement at the beginning but progressed rapidly and died shortly after despite aggressive chemotherapy. Due to its rarity, we present here a case of CD4+/CD56+ hematodermic neoplasm.
41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir... more 41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir. Sebebi genellikle benign bir bozukluk olmakla beraber; hir-sutizm nadiren androjen sekrete eden tümör veya Cushing sendromu gibi daha ciddi endokrinolojik hastalığın bir işareti olabilir. Bu çalışmanın amacı reprodüktif yaştaki hirsutizmli kadınlarda hirsutiz-min etiyolojik faktörlerini ve klinik özelliklerini or-taya koymaktı. Materyal ve Metod: Bu çalışmaya 2000-2006 tarih-leri arasında hirsutizm polikliniğimizde izlenen, ça-lışmadan dışlanma kriterleri uygulandıktan sonra geriye kalan 271 hasta dahil edildi. Verilere hirsut hasta dosyaları geriye dönük olarak taranarak ula-şıldı. Ulaşılan veriler detaylı klinik değerlendirme, endokrinolojik araştırma ve pelvik ultrasonografi bulgularından oluştu. Bulgular: Hirsutizmin etiyolojisinde %49,8 poli-kistik over sendromu (PKOS) ve %39,5 oranında idiopatik hirsutizm (İH) iki major grup olarak belir-lendi. Bunları sırasıyla %5,9 tanımlanamay...
European review for medical and pharmacological sciences
The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors... more The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors leading to the disease may include hypercoagulability, hypofibrinolysis and endothelial injury. We sought to evaluate the frequency of erythema nodosum-like lesions (ENLL) due to the presence of vasculitis in ENLL observed in BD in male patients with BD with and without deep vein thrombosis. To our knowledge this is the first study to investigate the association of ENLL between the groups with or without thrombosis in only male patients with BD. The study included 92 patients, 41 of whom had deep vein thrombosis (DVT) and 51 had no thrombosis that met the international diagnosis criteria for BD. Vascular involvement was diagnosed based on clinical signs; radiological findings from Doppler, ultrasonography and/or angiography computed tomographic or magnetic resonance. ENLL were diagnosed by means of biopsy in suspected cases. Since both groups were age-matched, there were no statisticall...
Background and Design: Behcet’s disease is a chronic, multisystem inflammatory disease of unknown... more Background and Design: Behcet’s disease is a chronic, multisystem inflammatory disease of unknown origin characterized mainly by recurrent oral aphthous ulceration, genital ulceration, skin lesions and uveitis. Thrombophilic defects, such as factor V Leiden (FVL) gene mutation may play a role in the pathogenesis of thrombosis in Behcet’s disease (BD). Recently, an association of FVL mutation with thrombosis and ocular involvement in BD has been reported. The object of this present study was to investigate an association between systemic involvement and the presence of the FVL gene mutation in BD patients.Material and Method: One-hundred six patients with BD and 70 healthy subjects were included in the study. FVL gene mutation was determined by polymerase chain reaction.Results: The FVL mutation was detected in 20.8% of the BD patients (22/106) compared with 8.5% of the control subjects (6/71). The difference was not statistically significant (p=0.027). Systemic involvement were obse...
Background and Design: The pemphigus family includes a number of disease which feature intraepide... more Background and Design: The pemphigus family includes a number of disease which feature intraepidermal blisters with acantholysis. Pemphigus vulgaris(PV) is the most common form of pemphigus, affects the skin and mucous membranes. Although oral mucosa is the most commonly affected site, all stratified squamous epithelium can be involved like pharynx, larynx, oesophagus, conjunctiva, vaginal, penile, and anal mucosa. We planned our study aiming to find frequency of oesophagus involvement in PV patients and to compare them immunohistopathologically with skin findings.Material and Method: Twenty three female and seven male patients, who were admitted to The Health Ministry Vakıf Gureba Education and Research Hospital, Dermatology Clinic, in between January 2004 and March 2005, and were accepted as PV according to clinical and immunohistopathological findings. Mucosal biopsies were taken by oesophagoscopy from patients in the same time with skin biopsies for DIF examination. Antibody tit...
Background and Design: The aims of our study were to determine the frequency of positive patch re... more Background and Design: The aims of our study were to determine the frequency of positive patch reactions and the most common allergens in patients with allergic contact dermatitis (ACD) and/or mucositis(M) who underwent with T.R.U.E. “Thin-layer Rapid-Use Epicutaneous” test and evaluate supplemantal series used with T.R.U.E. test effect on patch test results.Material and Method: In this study 161 ACD, 5 ACM, 1 ACD and ACM were enrolled. While 139 of all patients were patch tested with T.R.U.E. test alone,out of 28 patients were tested for T.R.U.E. test and also with supplemental series that included textile colours (9 of tested patients), plastic and glues (9), dental screening (6), backery (2), cosmetic (1) and plastic and glues and dental screening (1). Supplemental series were chosen according to patient’s occupation and clinic presentation. The data from our patients were analyzed as percentage. The relationship between contact sensitization and atopic status was evaluated with ...
Background and Design: Previous studies reported that there are some relations between psoriasis ... more Background and Design: Previous studies reported that there are some relations between psoriasis and the diabetes mellitus. However, incidence rates of diabetes mellitus in psoriasis and also incidence rates of psoriasis in diabetes mellitus are lacking.Our aim was to assess and compare incidence rates of diabetes mellitus in patients with psoriasis and incidence rates of psorasis in diabetes mellitus and also evaluate the role of psoriasis as a risk factor for diabetes mellitus. Material and Method: Four hundred eighteen patients with psoriasis and one hundred fifty four patients with diabetes were included. Blood glucose, oral glucose tolerance test (OGTT), glycolised hemoglobine (HbA1C) were performed in psoriatic patients and these results were consulted with diabetes clinic. Psoriasis screening by clinical history, dermatologic examination, skin biopsy; if it is necessary were held for patients with diabetes. Results: Prevalance of diabetes was 9.3% in psoriatic patients; preva...
Background and Design: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with J... more Background and Design: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with Jews, Italians and Greeks. Classic KS has been seen relatively frequently in Turkey. Our aim was to evaluate the demographic, clinical features of Kaposi sarcoma and etiopathological role of human herpesvirus-8 (HHV-8). Treatment results of 18 classic Kaposi’s sarcoma were also concluded.Material and Method: Eighteen cases of classic Kaposi sarcoma diagnosed as clinically and histopathologically between January 2001 and August 2008 in our dermatology department were taken to this study. Demographic, clinical features and treatment results were reviewed retrospectively in all patients. HHV-8 was investigated in the lesional skin of 7 patients.Results: A male/female ratio of 2/1 was found. Mean age at diagnosis was 67.2 (37-94) years. Bilaterally lower extremities were involved in 15 patients (83.3%), the trunk was involved in 3 patients (16.6%). Plaques and nodules were the common type of ...
Background and Design: Using an ultrasensitive assay, PSA has been detected in female serum and h... more Background and Design: Using an ultrasensitive assay, PSA has been detected in female serum and has been proposed as a potential marker of androgen excess in hirsute women. The object of this present study was to investigate an association between hirsutism and serum PSA levels.Material and Method: A total of 47 women with hirsutism and 24 age-matched nonhirsute women were included in this study. Using an ultrasensitive chemiluminescent immunoassay serum PSA were determined in all subjects.Results: Serum levels of PSA were higher in hirsute women than in nonhirsute controls (p<0.05).Conclusion: If more sensitive assays become available, PSA might be used as biochemical marker of peripheral androgen excess in women with hirsutism.
Background and Design: Our purpose was to compare the sensitivity, specificity, and diagnostic ac... more Background and Design: Our purpose was to compare the sensitivity, specificity, and diagnostic accuracy of the 7-point and 3-point checklist, on a series of dermoscopic images of melanoma lesions diagnosed as histopathologically. MATERIAL-METHOD: Fourty-seven preoperative dermoscopic photographs of histopathologically proven melanoma lesions were studied retroscopically. Each lesion was assessed using the 7-point and the 3-point checklist. Statistical Package for Social Sciences for Windows 10.0, decriptive statistical analyses and screening tests were performed. RESULTS: The 3-point checklist gave a sensitivity of %91,5 compared with the %89,4 sensitivity of the 7-point checklist. CONCLUSION: Both the 7-point checklist and the 3-point checklist can be easily learned and easily applied. The 7-point checklist, based on pattern analysis, provides more detailed analysis especially for the thin melanomas. The 3-point checklist, with its higher sensitivity, can allow to obtain higher dia...
Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin manifes... more Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin manifestations. Every patient needs to be treated individually upon to the severity of the disease, associated comorbidites and life style. Under the light of recent studies and publications proposing algorithms and treatment stratetegies psoriasis treatment is discussed here.
Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its preva... more Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its prevalence is however probably underestimated in dermatological literature. Early recognition of the signs can prevent misdiagnosis. We describe a Turkish patient who presented with palmoplantar pustulosis and involvement of the sternoclavicular joint and peripheral oligoarthritis.
The association between chronic idiopathic urticaria (CIU) and thyroid autoimmunity has most ofte... more The association between chronic idiopathic urticaria (CIU) and thyroid autoimmunity has most often been suggested in studies investigating thyroid microsomal antibodies, which are less sensitive and specific than anti-thyroperoxidase antibodies, moreover these studies were not case-control studies in large series. By comparing a large patient series presenting with CIU with a large numbered control group we aimed to learn the extent of autoimmune thyroid disease. We compared the frequency of thyroid autoantibodies in 140 patients with CIU with 181 age-and sex-matched volunteers. Thyroid function tests and thyroid autoantibodies were measured by chemiluminescent immunometric assay in study groups. The frequency of thyroid autoantibodies was significantly higher in patients with CIU than that in healthy controls (29.28 %/5.52%; p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Of 41 patients, 10 had thyroid dysfunction and the other cases were euthyroid. The higher frequency of these antibodies in our patients shows that there was a strong association between CIU and thyroid autoimmunity.
CD4+/CD56+ hematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm) involving the ski... more CD4+/CD56+ hematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm) involving the skin is relatively rare and has been of significant interest in the recent literature. We report here a 64-year-old male who presented with multiple purple-red nodules and plaques on his face, back, and chest. Histological examination of skin biopsies showed an intense hematolymphoid infiltration in the dermis and in the subcutaneous tissue. Stains were positive for CD4 (weak), CD56, and terminal deoxynucleotidyl transferase (TdT). These cells were negative for CD2, CD3, CD5, CD10, CD20, CD30, CD68, and T cell intracellular antigen (TIA). In situ hybridization (ISH) for Epstein-Barr virus was negative and the diagnosis was blastic NK cell lymphoma. The patient was treated with a hyper-CVAD regimen (cyclophosphamide, vincristine, doxorubicine, dexamethasone, methotrexate, and cytarabine).This treatment regimen achieved partial remission but the patient died eight months after the diagnosis. The patient presented with exclusively cutaneous involvement at the beginning but progressed rapidly and died shortly after despite aggressive chemotherapy. Due to its rarity, we present here a case of CD4+/CD56+ hematodermic neoplasm.
41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir... more 41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir. Sebebi genellikle benign bir bozukluk olmakla beraber; hir-sutizm nadiren androjen sekrete eden tümör veya Cushing sendromu gibi daha ciddi endokrinolojik hastalığın bir işareti olabilir. Bu çalışmanın amacı reprodüktif yaştaki hirsutizmli kadınlarda hirsutiz-min etiyolojik faktörlerini ve klinik özelliklerini or-taya koymaktı. Materyal ve Metod: Bu çalışmaya 2000-2006 tarih-leri arasında hirsutizm polikliniğimizde izlenen, ça-lışmadan dışlanma kriterleri uygulandıktan sonra geriye kalan 271 hasta dahil edildi. Verilere hirsut hasta dosyaları geriye dönük olarak taranarak ula-şıldı. Ulaşılan veriler detaylı klinik değerlendirme, endokrinolojik araştırma ve pelvik ultrasonografi bulgularından oluştu. Bulgular: Hirsutizmin etiyolojisinde %49,8 poli-kistik over sendromu (PKOS) ve %39,5 oranında idiopatik hirsutizm (İH) iki major grup olarak belir-lendi. Bunları sırasıyla %5,9 tanımlanamay...
European review for medical and pharmacological sciences
The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors... more The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors leading to the disease may include hypercoagulability, hypofibrinolysis and endothelial injury. We sought to evaluate the frequency of erythema nodosum-like lesions (ENLL) due to the presence of vasculitis in ENLL observed in BD in male patients with BD with and without deep vein thrombosis. To our knowledge this is the first study to investigate the association of ENLL between the groups with or without thrombosis in only male patients with BD. The study included 92 patients, 41 of whom had deep vein thrombosis (DVT) and 51 had no thrombosis that met the international diagnosis criteria for BD. Vascular involvement was diagnosed based on clinical signs; radiological findings from Doppler, ultrasonography and/or angiography computed tomographic or magnetic resonance. ENLL were diagnosed by means of biopsy in suspected cases. Since both groups were age-matched, there were no statisticall...
Background and Design: Behcet’s disease is a chronic, multisystem inflammatory disease of unknown... more Background and Design: Behcet’s disease is a chronic, multisystem inflammatory disease of unknown origin characterized mainly by recurrent oral aphthous ulceration, genital ulceration, skin lesions and uveitis. Thrombophilic defects, such as factor V Leiden (FVL) gene mutation may play a role in the pathogenesis of thrombosis in Behcet’s disease (BD). Recently, an association of FVL mutation with thrombosis and ocular involvement in BD has been reported. The object of this present study was to investigate an association between systemic involvement and the presence of the FVL gene mutation in BD patients.Material and Method: One-hundred six patients with BD and 70 healthy subjects were included in the study. FVL gene mutation was determined by polymerase chain reaction.Results: The FVL mutation was detected in 20.8% of the BD patients (22/106) compared with 8.5% of the control subjects (6/71). The difference was not statistically significant (p=0.027). Systemic involvement were obse...
Background and Design: The pemphigus family includes a number of disease which feature intraepide... more Background and Design: The pemphigus family includes a number of disease which feature intraepidermal blisters with acantholysis. Pemphigus vulgaris(PV) is the most common form of pemphigus, affects the skin and mucous membranes. Although oral mucosa is the most commonly affected site, all stratified squamous epithelium can be involved like pharynx, larynx, oesophagus, conjunctiva, vaginal, penile, and anal mucosa. We planned our study aiming to find frequency of oesophagus involvement in PV patients and to compare them immunohistopathologically with skin findings.Material and Method: Twenty three female and seven male patients, who were admitted to The Health Ministry Vakıf Gureba Education and Research Hospital, Dermatology Clinic, in between January 2004 and March 2005, and were accepted as PV according to clinical and immunohistopathological findings. Mucosal biopsies were taken by oesophagoscopy from patients in the same time with skin biopsies for DIF examination. Antibody tit...
Background and Design: The aims of our study were to determine the frequency of positive patch re... more Background and Design: The aims of our study were to determine the frequency of positive patch reactions and the most common allergens in patients with allergic contact dermatitis (ACD) and/or mucositis(M) who underwent with T.R.U.E. “Thin-layer Rapid-Use Epicutaneous” test and evaluate supplemantal series used with T.R.U.E. test effect on patch test results.Material and Method: In this study 161 ACD, 5 ACM, 1 ACD and ACM were enrolled. While 139 of all patients were patch tested with T.R.U.E. test alone,out of 28 patients were tested for T.R.U.E. test and also with supplemental series that included textile colours (9 of tested patients), plastic and glues (9), dental screening (6), backery (2), cosmetic (1) and plastic and glues and dental screening (1). Supplemental series were chosen according to patient’s occupation and clinic presentation. The data from our patients were analyzed as percentage. The relationship between contact sensitization and atopic status was evaluated with ...
Background and Design: Previous studies reported that there are some relations between psoriasis ... more Background and Design: Previous studies reported that there are some relations between psoriasis and the diabetes mellitus. However, incidence rates of diabetes mellitus in psoriasis and also incidence rates of psoriasis in diabetes mellitus are lacking.Our aim was to assess and compare incidence rates of diabetes mellitus in patients with psoriasis and incidence rates of psorasis in diabetes mellitus and also evaluate the role of psoriasis as a risk factor for diabetes mellitus. Material and Method: Four hundred eighteen patients with psoriasis and one hundred fifty four patients with diabetes were included. Blood glucose, oral glucose tolerance test (OGTT), glycolised hemoglobine (HbA1C) were performed in psoriatic patients and these results were consulted with diabetes clinic. Psoriasis screening by clinical history, dermatologic examination, skin biopsy; if it is necessary were held for patients with diabetes. Results: Prevalance of diabetes was 9.3% in psoriatic patients; preva...
Background and Design: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with J... more Background and Design: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with Jews, Italians and Greeks. Classic KS has been seen relatively frequently in Turkey. Our aim was to evaluate the demographic, clinical features of Kaposi sarcoma and etiopathological role of human herpesvirus-8 (HHV-8). Treatment results of 18 classic Kaposi’s sarcoma were also concluded.Material and Method: Eighteen cases of classic Kaposi sarcoma diagnosed as clinically and histopathologically between January 2001 and August 2008 in our dermatology department were taken to this study. Demographic, clinical features and treatment results were reviewed retrospectively in all patients. HHV-8 was investigated in the lesional skin of 7 patients.Results: A male/female ratio of 2/1 was found. Mean age at diagnosis was 67.2 (37-94) years. Bilaterally lower extremities were involved in 15 patients (83.3%), the trunk was involved in 3 patients (16.6%). Plaques and nodules were the common type of ...
Background and Design: Using an ultrasensitive assay, PSA has been detected in female serum and h... more Background and Design: Using an ultrasensitive assay, PSA has been detected in female serum and has been proposed as a potential marker of androgen excess in hirsute women. The object of this present study was to investigate an association between hirsutism and serum PSA levels.Material and Method: A total of 47 women with hirsutism and 24 age-matched nonhirsute women were included in this study. Using an ultrasensitive chemiluminescent immunoassay serum PSA were determined in all subjects.Results: Serum levels of PSA were higher in hirsute women than in nonhirsute controls (p<0.05).Conclusion: If more sensitive assays become available, PSA might be used as biochemical marker of peripheral androgen excess in women with hirsutism.
Background and Design: Our purpose was to compare the sensitivity, specificity, and diagnostic ac... more Background and Design: Our purpose was to compare the sensitivity, specificity, and diagnostic accuracy of the 7-point and 3-point checklist, on a series of dermoscopic images of melanoma lesions diagnosed as histopathologically. MATERIAL-METHOD: Fourty-seven preoperative dermoscopic photographs of histopathologically proven melanoma lesions were studied retroscopically. Each lesion was assessed using the 7-point and the 3-point checklist. Statistical Package for Social Sciences for Windows 10.0, decriptive statistical analyses and screening tests were performed. RESULTS: The 3-point checklist gave a sensitivity of %91,5 compared with the %89,4 sensitivity of the 7-point checklist. CONCLUSION: Both the 7-point checklist and the 3-point checklist can be easily learned and easily applied. The 7-point checklist, based on pattern analysis, provides more detailed analysis especially for the thin melanomas. The 3-point checklist, with its higher sensitivity, can allow to obtain higher dia...
Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin manifes... more Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin manifestations. Every patient needs to be treated individually upon to the severity of the disease, associated comorbidites and life style. Under the light of recent studies and publications proposing algorithms and treatment stratetegies psoriasis treatment is discussed here.
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