- Заглавие:
Dysregulation of brain dopamine systems in major depressive disorder
- Автор:
Delva N. C.
- Аннотация:
Major depressive disorder (MDD or depression) is a debilitating neuropsychiatric syndrome with genetic, epigenetic, and environmental contributions. Depression is one of the largest contributors to chronic disease burden; it affects more than one in six individuals in the United States. A wide array of cellular and molecular modifications distributed across a variety of neuronal processes and circuits underlie the pathophysiology of depression-no established mechanism can explain all aspects of the disease. MDD suffers from a vast treatment gap worldwide, and large numbers of individuals who require treatment do not receive adequate care. This mini-review focuses on dysregulation of brain dopamine (DA) systems in the pathophysiology of MDD and describing new cellular targets for potential medication development focused on DA-modulated micro-circuits. We also explore how neurodevelopmental factors may modify risk for later emergence of MDD, possibly through dopaminergic substrates in the brain.
- Язык текста:
Английский
- Сведения об источнике:
Experimental biology and medicine. – 2021. – Vol. 246, № 9. – P. 1084–1093.
- Электронная версия:
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Библиографический источник
Dysregulation of brain dopamine systems in major depressive disorder
N. C. Delva, G. D. Stanwood