S Wikipedije, slobodne enciklopedije
Formin-vezujući protein 4 je protein koji je kod ljudi kodiran genom FNBP4 .[ 5] [ 6]
Pronađene su mutacije u ovom genu povezane sa slučajevima sličnim mikroftalmiji s anomalijama udova.
Dužina polipeptidnog lanca je 1.o17 aminokiselina , a molekulska težina 110.266 Da .[ 7]
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MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA
PSAATTTTTA VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA
VKATGGLCLL GAYADSDDDD NDVSEKLAQS KETNGNQSTD IDSTLANFLA
EIDAITAPQP AAPVGASAPP PTPPRPEPKE AATSTLSSST SNGTDSTQTS
GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE VTWELPQYLA
TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV
KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE
PVSEVKETST TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE
EQDTLELELV LERKKAELRA LEEGDGSVSG SSPRSDISQP ASQDGMRRLM
SKRGKWKMFV RATSPESTSR SSSKTGRDTP ENGETAIGAE NSEKIDENSD
KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK FEFLGINRQS
ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG
WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT
LKDKTGTDSN STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV
PVLQPPLPLE MPPPPPPPPE SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP
PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI SSSSSTKGIK RKATEISTAV
VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI PVSLPAAGMG
HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA
TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW
QSIQRELDEE DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL
PEDWRARLKR RKMAPNT
^ a b c ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 - Ensembl , maj 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008200 - Ensembl , maj 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (1): 63–70. doi :10.1093/dnares/6.1.63 . PMID 10231032 .
^ "Entrez Gene: FNBP4 formin binding protein 4" .
^ "UniProt, Q8N3X1" . Pristupljeno 22. 8. 2021 .
Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains" . J. Biol. Chem . 275 (14): 10359–69. doi :10.1074/jbc.275.14.10359 . PMID 10744724 .
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains" . J. Biol. Chem . 275 (21): 16030–6. doi :10.1074/jbc.M909368199 . PMID 10748127 .
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol . 307 (5): 1329–39. doi :10.1006/jmbi.2001.4572 . PMID 11292345 .
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs" . Genome Res . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 . PMID 12421765 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 . PMID 15231748 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .