HLA-DRB3
DRB3-1 beta lanac HLA klase II antigena histokompatibilmosti jest protein koji je kod ljudi kodiran genom HLA-DRB3 sa hromosoma 6.[2]
Funkcija
[uredi | uredi izvor]Protein kodiran ovim genom pripada HLA klasi II beta lanca paraloga. Molekula klase II je heterodimer koji se sastoji od alfa (DRA) i beta lanca (DRB), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu prezentirajući peptide izvedene iz vanćelijskih proteina. Molekule klase II eksprimirane su u ćelijama koje prezentiraju antigen (APC: B-limfociti, dendritske ćelije, makrofagi).[2]
Struktura gena i polimorfizmi
[uredi | uredi izvor]Beta lanac je otprilike 26-28 kDa. Kodira ga šest egzona; egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva ekstracelularna domena, egzon 4 kodira transmembranski domen i egzon 5 kodira citoplazmatski rep. Unutar DR molekula, beta lanac sadrži sve polimorfizme koji određuju specifičnosti vezivanja peptida. Tipizacija za ove polimorfizme radi se rutinski za transplantaciju koštane srži i transplantaciju bubrega.[2]
DRB1 eksprimiran je na nivou pet puta većem od njegovih paraloga DRB3, DRB4 i DRB5. DRB1 je prisutan kod svih osobaa. Alelne varijante DRB1 su povezane ni sa jednim ili sa jednim od gena DRB3, DRB4 i DRB5. Postoje četiri srodna pseudogena: DRB2, DRB6, DRB7, DRB8 i DRB9.[2]
Također pogledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d "Entrez Gene: HLA-DRB3 major histocompatibility complex, class II, DR beta 3".
Dopunska literatura
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- Kao HT, Gregersen PK, Tang JC, et al. (1989). "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3". J. Immunol. 142 (5): 1743–7. PMID 2493052.
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- Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
- Angelini G, de Preval C, Gorski J, Mach B (1986). "High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes". Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4489–93. Bibcode:1986PNAS...83.4489A. doi:10.1073/pnas.83.12.4489. PMC 323759. PMID 3012569.
- Didier DK, Schiffenbauer J, Shuman S, et al. (1986). "Characterization of two distinct DR beta chain alleles at the beta III locus of the DR5 haplotype: beta III alleles are highly conserved". J. Immunol. 137 (8): 2627–31. PMID 3020126.
- Young JA, Wilkinson D, Bodmer WF, Trowsdale J (1987). "Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4929–33. Bibcode:1987PNAS...84.4929Y. doi:10.1073/pnas.84.14.4929. PMC 305220. PMID 3110774.
- Horn GT, Bugawan TL, Long CM, et al. (1988). "Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals". Hum. Immunol. 21 (4): 249–63. doi:10.1016/0198-8859(88)90034-1. PMID 3372263.
- Gorski J, Mach B (1986). "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR specificity". Nature. 322 (6074): 67–70. Bibcode:1986Natur.322...67G. doi:10.1038/322067a0. PMID 3459965. S2CID 4358343.
- Gregersen PK, Moriuchi T, Karr RW, et al. (1987). "Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9149–53. doi:10.1073/pnas.83.23.9149. PMC 387092. PMID 3466180.
- Bell JI, Denney D, Foster L, et al. (1987). "Allelic variation in the DR subregion of the human major histocompatibility complex". Proc. Natl. Acad. Sci. U.S.A. 84 (17): 6234–8. Bibcode:1987PNAS...84.6234B. doi:10.1073/pnas.84.17.6234. PMC 299045. PMID 3476943.
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