PISD
Izgled
Proenzim fosfatiduilserin-dekarboksilaza jest enzim koji je kod ljudi kodiran genom PISD sa hromosoma 22.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 409 aminokiselina, a molekulska težina 46.672 Da[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MATSVGHRCL | GLLHGVAPWR | SSLHPCEITA | LSQSLQPLRK | LPFRAFRTDA | ||||
RKIHTAPART | MFLLRPLPIL | LVTGGGYAGY | RQYEKYRERE | LEKLGLEIPP | ||||
KLAGHWEVAL | YKSVPTRLLS | RAWGRLNQVE | LPHWLRRPVY | SLYIWTFGVN | ||||
MKEAAVEDLH | HYRNLSEFFR | RKLKPQARPV | CGLHSVISPS | DGRILNFGQV | ||||
KNCEVEQVKG | VTYSLESFLG | PRMCTEDLPF | PPAASCDSFK | NQLVTREGNE | ||||
LYHCVIYLAP | GDYHCFHSPT | DWTVSHRRHF | PGSLMSVNPG | MARWIKELFC | ||||
HNERVVLTGD | WKHGFFSLTA | VGATNVGSIR | IYFDRDLHTN | SPRHSKGSYN | ||||
DFSFVTHTNR | EGVPMRKGEH | LGEFNLGSTI | VLIFEAPKDF | NFQLKTGQKI | ||||
RFGEALGSL |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000241878 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023452 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ^ a b "Entrez Gene: PISD phosphatidylserine decarboxylase".
Dopunska literatura
[uredi | uredi izvor]- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Kuge O, Saito K, Kojima M, Akamatsu Y, Nishijima M (1996). "Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells". Biochem. J. 319 ( Pt 1) (Pt 1): 33–8. PMC 1217732. PMID 8870646.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
- Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE (2006). "Disruption of the Phosphatidylserine Decarboxylase Gene in Mice Causes Embryonic Lethality and Mitochondrial Defects". J. Biol. Chem. 280 (48): 40032–40. doi:10.1074/jbc.M506510200. PMC 2888304. PMID 16192276.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ (2007). "High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase". Journal of Biomolecular Screening. 12 (5): 628–34. doi:10.1177/1087057107301320. PMID 17478478.