TECPR1
Izgled
Tektonin sa beta-propelerskim ponavljanjem 1 jest protein koji je kod ljudi kodiran genom TECPR1.[5]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 1.165 aminokiselina, а molekulska težina 129.696 Da.[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MPNSVLWAVD | LFGRVYTLST | AGQYWEMCKD | SQLEFKRVSA | TTQCCWGIAC | ||||
DNQVYVYVCA | SDVPIRRREE | AYENQRWNPM | GGFCEKLLLS | DRWGWSDVSG | ||||
LQHRPLDRVA | LPSPHWEWES | DWYVDENFGG | EPTEKGGWTY | AIDFPATYTK | ||||
DKKWNSCVRR | RKWIRYRRYK | SRDIWAKIPS | KDDPKELPDP | FNDLSVGGWE | ||||
ITEEPVGRLS | VWAVSLQGKV | WYREDVSHSN | PEGSSWSLLD | TPGEVVQISC | ||||
GPHDLLWATL | WEGQALVREG | INRSNPKGSS | WSIVEPPGSE | NGVMHISVGV | ||||
SVVWAVTKDW | KVWFRRGVNS | HNPCGTSWIE | MVGEMTMVNV | GMNDQVWGIG | ||||
CEDRAVYFRQ | GVTPSELSGK | TWKAIIAARE | CDRSHSGSSS | SLLSAGCFFG | ||||
DEVRGSGESA | PSDTDASSEV | ERPGPGQILP | AEPLDDSKNA | TGNSASGLGA | ||||
GRTAEDTVED | ACPAEGSREA | RPNTHPGPAP | TPAELPWTNI | DLKEAKKVPS | ||||
HSAAGFPETT | SLSSLGLLPL | GLEEPYGVDD | HPLWAWVSGG | GCVVEACAMP | ||||
RWFTVQAGLS | SSVHMLSLSI | TPAQTAAWRK | QIFQQLTERT | KRELENFRHY | ||||
EQAVEQSVWV | KTGALQWWCD | WKPHKWVDVR | LALEQFTGHD | GVRDSILFIY | ||||
YVVHEEKKYI | HIFLNEVVAL | VPVLNETKHS | FALYTPERTR | QRWPVRLAAA | ||||
TEQDMNDWLA | LLSLSCCESR | KVQGRPSPQA | IWSITCKGDI | FVSEPSPDLE | ||||
AHEHPLPCDQ | MFWRQMGGHL | RMVEANSRGV | VWGIGYDHTA | WVYTGGYGGG | ||||
CFQGLASSTS | NIYTQSDVKC | VHIYENQRWN | PVTGYTSRGL | PTDRYMWSDA | ||||
SGLQECTKAG | TKPPSLQWAW | VSDWFVDFSV | PGGTDQEGWQ | YASDFPASYH | ||||
GSKTMKDFVR | RRCWARKCKL | VTSGPWLEVP | PIALRDVSII | PESPGAEGSG | ||||
HSIALWAVSD | KGDVLCRLGV | SELNPAGSSW | LHVGTDQPFA | SISIGACYQV | ||||
WAVARDGSAF | YRGSVYPSQP | AGDCWYHIPS | PPRQRLKQVS | AGQTSVYALD | ||||
ENGNLWYRQG | ITPSYPQGSS | WEHVSNNVCR | VSVGPLDQVW | VIANKVQGSH | ||||
SLSRGTVCHR | TGVQPHEPKG | HGWDYGIGGG | WDHISVRANA | TRAPRSSSQE | ||||
QEPSAPPEAH | GPVCC |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira faktor vezivanja uključen u autofagiju. Kodirani protein nalazi se na autolizosomima i uključen je u ciljanje proteinskih agregata, oštećenih mitohondrija i bakterijskih patogena za autofagiju.
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000205356 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066621 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Tectonin beta-propeller repeat containing 1". Pristupljeno 3. 1. 2017.
- ^ "UniProt, Q7Z6L1" (jezik: engleski). Pristupljeno 29. 9. 2021.