File:Dead-box crystal structure.png

English: (A) Superposition of the DEAD-domains of DDX2A (green), DDX2B (brown), DDX5 (red), DDX10 (turquoise), DDX18 (grey), DDX47 (dark blue), DDX52 (yellow), and DDX53 (dark yellow). The positions of conserved motifs I–III (black) are indicated. (B) Superposition of the helicase domains of DDX19 (light blue), DDX25 (grey) and DDX41 (orange). The positions of conserved motifs IV–VI (black) are indicated. (C) Cartoon representations of the DDX5 helicase domain in the same orientations as in the following two panels. (D) Conserved surface patches (green), projected onto the DDX47 DEAD-domain surface. (E) Electrostatic surface representation of DEAD-domains. Negative charges are shown in red and positive charges in blue. (F) Cartoon representations of the DDX41 helicase domain in the same orientation as in the following two panels. The RNA and AMPPNP (sticks representation) of the superposed DDX19 structure mark the RNA and nucleotide binding sites. (G) Conserved surface patches (green), projected onto the DDX25 helicase-domain surface. (H) Electrostatic surface representation of helicase domains.