File:Stem cells, Hues 9 p 23.jpg
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English: Knee Stem Cells for Arthritis and Joint Injuries
CAN STEM CELLS CURE KNEE ARTHRITIS? This is an interesting point. First, what is our definition of arthritis? Second, what affect do stem cells exert upon the arthritic knee joint? The most typical reference to arthritis is for osteoarthritis. Osteoarthritis is typically associated with wear and tear, yet it is much more complex. Rheumatoid arthritis is much less common than osteoarthritis, and is an autoimmune disorder. Stem cells may exert several roles in the repair of knee osteoarthritis. Stem cells may act as anti-inflammatory mediators, and stem cells may form new cartilage or bone cells, by differentiation. WHAT IS KNEE OSTEOARTHRITIS? A working definition of knee osteoarthritis is the degeneration of the knee joint. The knee is composed of cartilage and bone. When the cartilage wears sufficiently, the underlying bone degrades, and the joint is compromised Knee Stem Cells for Arthritis. The spectrum of knee joint osteoarthritis is from the beginning to the end stage. The onset of knee arthritis may occur from trauma. This imparts a set ground zero for the development of knee osteoarthritis. This trauma may resolve without knee continued knee pain, however the destructive process has occurred. The normal knee is in a state of balance between knee cartilage breakdown and repair. When breakdown exceeds repair, degeneration occurs. Over time the spectrum of osteoarthritis is magnified and at this point x-ray or MRI changes may be seen. Initial subclinical knee osteoarthritis is not visualized on imaging such as x-Rays. It may be thought of as a chemical imbalance of the knee joint. Inflammatory chemicals or mediators breakdown the knee, while anti-inflammatory mediators repair the knee joint. Simply stated knee arthritis is there before you you really know it. That is the bad news. This imparts a meeting of Preventative and Regenerative Medicine. An ounce of prevention is worth a pound of cure. That could be extrapolated many ways in stem cell medicine. Microscopic image of stem cells, Hues 9 p 23 on mouse embryonic fibroblast feeder; 10 x |
| Date | |
| Source | Own work |
| Author | UCSanDiegoStemCellProgram |
This photo was taken by Karl Marquez of the University of California, San Diego at the Sanford Consortium for Regenerative Medicine.
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| current | 20:01, 26 February 2014 | | 1,388 × 1,040 (660 KB) | UCSanDiegoStemCellProgram (talk | contribs) | User created page with UploadWizard |
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