CD74

CD74
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W
Dynodwyr
Cyfenwau	CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
Dynodwyr allanol	OMIM: 142790 HomoloGene: 3209 GeneCards: CD74
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nitric-oxide synthase binding; • identical protein binding; • MHC class II protein binding, via antigen binding groove; • GO:0016518 cytokine receptor activity; • macrophage migration inhibitory factor binding; • protein folding chaperone activity; • MHC class II protein complex binding; • amyloid-beta binding; • GO:0001948, GO:0016582 protein binding; • MHC class II protein binding; • GO:0019974 cytokine binding; • CD4 receptor binding;
Cydrannau o'r gell	• lysosomal lumen; • extracellular exosome; • MHC class II protein complex; • lysosomal membrane; • late endosome; • endocytic vesicle membrane; • transport vesicle membrane; • integral component of membrane; • ER to Golgi transport vesicle membrane; • multivesicular body; • Golgi apparatus; • Golgi membrane; • trans-Golgi network membrane; • macrophage migration inhibitory factor receptor complex; • bilen; • cell surface; • intracellular anatomical structure; • integral component of lumenal side of endoplasmic reticulum membrane; • Reticwlwm endoplasmig; • endoplasmic reticulum membrane; • Cellbilen; • lysosome; • vacuole; • endosome; • clathrin-coated endocytic vesicle membrane; • NOS2-CD74 complex; • external side of plasma membrane;
Prosesau biolegol	• GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of T cell differentiation; • negative regulation of apoptotic process; • GO:0072468 signal transduction; • positive thymic T cell selection; • chaperone cofactor-dependent protein refolding; • T cell selection; • positive regulation of type 2 immune response; • positive regulation of dendritic cell antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • adaptive immune response; • antigen processing and presentation; • positive regulation of peptidyl-tyrosine phosphorylation; • negative regulation of mature B cell apoptotic process; • regulation of macrophage activation; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • immunoglobulin mediated immune response; • leukocyte migration; • positive regulation of neutrophil chemotaxis; • positive regulation of chemokine (C-X-C motif) ligand 2 production; • macrophage migration inhibitory factor signaling pathway; • prostaglandin biosynthetic process; • cell population proliferation; • antigen processing and presentation of endogenous antigen; • immune system process; • defense response; • negative regulation of peptide secretion; • negative regulation of T cell differentiation; • positive regulation of macrophage cytokine production; • positive regulation of B cell proliferation; • negative thymic T cell selection; • positive regulation of fibroblast proliferation; • intracellular protein transport; • positive regulation of ERK1 and ERK2 cascade; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • positive regulation of cytokine-mediated signaling pathway; • positive regulation of protein phosphorylation; • positive regulation of kinase activity; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of MAPK cascade; • positive regulation of monocyte differentiation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of viral entry into host cell; • protein heterotetramerization; • protein trimerization; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	972
	n/a
	ENSG00000019582
	n/a
	P04233
	n/a
	NM_004355; NM_001025158; NM_001025159; NM_001364083; NM_001364084
	n/a
	NP_001020329; NP_001020330; NP_004346; NP_001351012; NP_001351013
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD74 yw CD74 a elwir hefyd yn HLA class II histocompatibility antigen gamma chain a CD74 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD74.

II
DHLAG
HLADG
Ia-GAMMA

Llyfryddiaeth

"CD74 and intratumoral immune response in breast cancer. ". Oncotarget. 2017. PMID 27058619.
"The multifaceted roles of the invariant chain CD74--More than just a chaperone. ". Biochim Biophys Acta. 2016. PMID 27033518.
"CD74 expression and its therapeutic potential in thyroid carcinoma. ". Endocr Relat Cancer. 2015. PMID 25600560.
"MIF Receptor CD74 is Restricted to Microglia/Macrophages, Associated with a M1-Polarized Immune Milieu and Prolonged Patient Survival in Gliomas. ". Brain Pathol. 2015. PMID 25175718.
"High class II-associated invariant chain peptide expression on residual leukemic cells is associated with increased relapse risk in acute myeloid leukemia.". Leuk Res. 2014. PMID 24731748.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CD74 - Cronfa NCBI

[1]

[2]