PBX3 Dynodwyr Cyfenwau PBX3 , PBX homeobox 3Dynodwyr allanol OMIM: 176312 HomoloGene: 21243 GeneCards: PBX3 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cnewyllyn cell • transcription regulator complex Prosesau biolegol • regulation of respiratory gaseous exchange by nervous system process • adult locomotory behavior • anterior compartment pattern formation • dorsal spinal cord development • neuron development • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • posterior compartment specification • respiratory gaseous exchange by respiratory system • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn PBX3 yw PBX3 a elwir hefyd yn Pre-B-cell leukemia transcription factor 3 a PBX homeobox 3 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.3.[ 2]
"Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects. ". Eur J Med Genet . 2012. PMID 22426282 .
"Regulation of PBX3 expression by androgen and Let-7d in prostate cancer. ". Mol Cancer . 2011. PMID 21548940 .
"PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. ". Int J Cancer . 2017. PMID 28411381 .
"PBX3 is a putative biomarker of aggressive prostate cancer. ". Int J Cancer . 2016. PMID 27273830 .
"PBX3 is overexpressed in gastric cancer and regulates cell proliferation. ". Tumour Biol . 2014. PMID 24375258 .