PIK3CA

PIK3CA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP
Dynodwyr
Cyfenwau	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, CLAPO, CCM4
Dynodwyr allanol	OMIM: 171834 HomoloGene: 21249 GeneCards: PIK3CA
EC number	2.7.11.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activator activity; • 1-phosphatidylinositol-4-phosphate 3-kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • insulin receptor substrate binding; • ATP binding; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • kinase activity; • phosphatidylinositol 3-kinase activity; • phosphatidylinositol-3,4-bisphosphate 5-kinase activity;
Cydrannau o'r gell	• phosphatidylinositol 3-kinase complex; • cytosol; • phosphatidylinositol 3-kinase complex, class IA; • Cellbilen; • lamellipodium; • cytoplasm; • bilen;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • cardiac muscle contraction; • epidermal growth factor receptor signaling pathway; • protein kinase B signaling; • Fc-gamma receptor signaling pathway involved in phagocytosis; • regulation of multicellular organism growth; • T cell costimulation; • hypomethylation of CpG island; • positive regulation of peptidyl-serine phosphorylation; • platelet activation; • Fc-epsilon receptor signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • vascular endothelial growth factor receptor signaling pathway; • vasculature development; • angiogenesis; • insulin receptor signaling pathway via phosphatidylinositol 3-kinase; • glucose metabolic process; • ffagocytosis; • energy homeostasis; • negative regulation of fibroblast apoptotic process; • regulation of gene expression; • liver development; • adipose tissue development; • regulation of cellular respiration; • T cell receptor signaling pathway; • activation of protein kinase activity; • regulation of genetic imprinting; • negative regulation of anoikis; • cellular response to glucose stimulus; • endothelial cell migration; • phosphatidylinositol-mediated signaling; • leukocyte migration; • ERBB2 signaling pathway; • phosphatidylinositol-3-phosphate biosynthetic process; • axon guidance; • negative regulation of macroautophagy; • phosphorylation; • positive regulation of TOR signaling; • anoikis; • adaptive immune response; • protein phosphorylation; • inflammatory response; • innate immune response; • cell chemotaxis; • G protein-coupled receptor signaling pathway; • positive regulation of protein kinase B signaling; • phosphatidylinositol 3-kinase signaling; • cytokine-mediated signaling pathway; • cell migration; • positive regulation of phosphatidylinositol 3-kinase signaling; • phosphatidylinositol biosynthetic process; • regulation of protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	5290
	n/a
	ENSG00000121879
	n/a
	P42336
	n/a
	NM_006218
	n/a
	NP_006209
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIK3CA yw PIK3CA a elwir hefyd yn Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform a Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q26.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIK3CA.

MCM
CWS5
MCAP
PI3K
CLOVE
MCMTC
PI3K-alpha
p110-alpha

Llyfryddiaeth

"Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer. ". J Surg Res. 2017. PMID 28550907.
"PI3K Overexpression and PIK3CA Mutations Are Associated with Age, Tumor Staging, and Other Clinical Characteristics in Chinese Patients with Esophageal Squamous Cell Carcinoma. ". Genet Test Mol Biomarkers. 2017. PMID 28384037.
"Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum. ". Am J Med Genet A. 2017. PMID 28328134.
"PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases. ". Oncotarget. 2017. PMID 28206962.
"Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2- advanced breast cancer: results from BOLERO-2.". Br J Cancer. 2017. PMID 28183140.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PIK3CA - Cronfa NCBI

[1]

[2]