Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes
Figure 3
ROC curves prediction from loci in the MHC region.
Prediction using six single nucleotide polymorphisms (SNPs) is shown in red, while prediction using HLA-DRB1 is shown in green. These curves (and those in Figures 4 and 5) were obtained by fitting logistic regression models as described in Text S1 and calculating the proportions of cases and controls with prediction scores exceeding each possible value. The dashed curve corresponds to the theoretical curve for the polygenic multiplicative model with λs = 3.13.