The impact of SBF2 on taxane-induced peripheral neuropathy
Fig 3
Silencing SBF2 in iPSC-dSN exacerbates paclitaxel-induced morphology phenotype.
A) Representative images of neurite outgrowth. Neurite outgrowths are stained by βIII-tubulin (green) and cell nuclei are stained with Hoeschst 33342 dye (blue). Scale bars = 1000 μm. B) Average neurite outgrowth of paclitaxel-treated NTC and siSBF2 cells relative to baseline (vehicle-treated cells) for visualization. The graph represents all six cell lines compiled and performed in triplicates. (NTC = non-targeted control, PTX = paclitaxel, ** = p<0.01, *** = p<0.001). Error bars represent SEM.