Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum
Fig 2
Functional analysis based on differentially expressed genes (DEGs).
(A) Dynamics of changes in expression of genes enriched for general biological process networks annotated by GeneGO Metacore. (B) Interferon signaling process network associated with blood transcriptional profile of VL patients compared to uninfected controls. The network between differentially expressed genes were calculated with the “analyze network” algorithm from the GeneGO MetaCore database. Circles represent DEGs between VL patients and uninfected controls, while triangles represent DEGs between VL patients and asymptomatic individuals. Red and blue depict up-regulated and down-regulated genes, respectively. Green arrows indicate positive interaction, red arrows indicate negative interactions and gray arrows indicate unspecified interactions. See MetaCore website for detailed legend at https://portal.genego.com/legends/MetaCoreQuickReferenceGuide.pdf. (C) GeneGO Metacore pathway enrichment analysis of up-regulated or down-regulated genes using a FDR <0.05. Pathways that were not associated with a particular transcriptional profile are depicted in gray.