Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 1
Domain-centric mechanisms of host-virus protein-protein interaction.
(A) A domain-domain interaction (DDI) example [43]: a cyclin domain-containing protein from Saimiriine herpesvirus 2 (red) targets a human CDK6 kinase domain (white). (B) A domain-motif interaction (DMI) example [44]: human retinoblastoma-associated protein (white) contains a linear motif-binding (LMB) domain which recognizes the peptide motif LxCxE (red) in the human papillomavirus E7 protein.