Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 4
Binding site mimicry evolves differently in virus and host proteins.
Two proteins can participate in DDIs with a common target by binding to: (A) different domains in the target; (B) the same domain in the target using different interaction domains; or, (C) the same domain in the target using the same interaction domain. (D) Viral proteins are significantly less likely than human proteins to bind to the same domain of a human protein by means of domain sequence similarity to an endogenous binding partner (Fisher's exact test, two-tailed P<10−10).