Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 5
Viruses tend to target human proteins containing linear motif-binding (LMB) domains.
We compared domain composition of generic human proteins in the endogenous network (blue) to human proteins targeted by viruses (“viral targets”, red). The vertical axis indicates the fraction of proteins in a group containing LMB domains; the horizontal axis indicates the fraction of proteins containing non-LMB domains. Relative to generic human proteins, human proteins targeted by viruses are significantly more likely to contain an LMB domain (vertical axis; Fisher's exact test, two-tailed P<10−15), and are slightly less likely to contain non-LMB domains (horizontal axis; P = 0.012).