Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 6
Preferential targeting of LMB domains by viruses is independent of host protein degree.
We partitioned human proteins into LMB domain-containing proteins (filled green points), and LMB domain-free proteins (open black points). We further divided proteins according to endogenous degree. 92% of all human proteins in the network fall into one of the degree 1–20 bins; each bin contains at least 20 proteins. The probability of being a viral target increases with degree for both LMB domain-containing and LMB domain-free proteins. For a given degree, LMB domain-containing proteins are more likely to be viral targets than LMB domain-free proteins.