Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 7
Viral proteins have a higher fraction of domain-motif interactions (DMIs) than human proteins.
Fraction of DMIs out of the total number of interactions per protein tend to be higher in viral proteins (red) than human proteins (blue) in (A) all interactions in the network (permutation test, two-tailed P = 0.047), and (B) confirmed interactions (P = 0.018). Error bars reflect the standard error.