Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 8
Viral proteins target LMB domains at greater density than human proteins.
Viral proteins (red) target significantly more unique LMB domains per residue than human proteins (blue) in (A) all interactions in the network (permutation test, two-tailed P = 0.012), and an independently generated human-virus PPI network [37], [38] (P = 0.049). (B) Viral proteins also have significantly more unique LMB motif types per residue than human proteins (P<0.001). Error bars reflect the standard error.