Journal of the Serbian Chemical Society 2001 Volume 66, Issue 1, Pages: 9-16
https://doi.org/10.2298/JSC0101009C
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Synthesis and reactivity of some mannich bases. VIII. Studies on several mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives
Comanita Eugenia ("Gh. Asachi" Technical University, Department of Organic Chemistry, Romania)
Roman Gheorghe ("Transilvania" University, Chemistry Department, Romania)
Popovici Irina ("Gr. T. Popa" University of Medicine and Pharmacy, Romania)
Comanita Bogdan (National Research Council of Canada, Institute for Chemical Process and Environmental Technology, Ottawa, Canada)
The synthesis of several Mannich bases resulting from the reaction of
2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines
is reported. Another series of products was obtained from N,N-dimethyl
substituted Mannich bases by replacing the amino group with pyrrolidine.
Most of the Mannich bases were transformed into oximes by treatment with
hydroxylamine hydrochloride in 10% NaOH.
Keywords: ortho-phenolic ketones, Mannich bases, amine exchange reaction, Mannichbases oximes