doiSerbia

Synthesis and antimicrobial, antifungal and anthelmintic activities of 3h-1,5-benzodiazepine derivatives

Kumar Rajesh (Department of Chemistry, University of Rajasthan, Jaipur, India)
Joshi Y.C. (Department of Chemistry, University of Rajasthan, Jaipur, India)

The diazonium salt of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide in the presence of sodium hydroxide was condensed with different β-diketones/β-ketoesters, 3a-e, to obtain new β-diketones/β-ketoesters, 4a-e. The β-diketones/β-ketoesters 4a-e were condensed with o-phenylenediamine (o-PDA) in presence of p-toluenesulfonic acid/SiO2 to give biologically active 3H-1,5-benzodiazepines, 5a-e. All the newly synthesized compounds were characterized by elemental analysis and spectral studies. The compounds 5a-e were screened for their antimicrobial, antifungal and anthelmintic activities.

Keywords: 1,5-benzodiazepines, β-diketones/β-ketoesters, substituted pyrazole, p-toluenesulfonic acid