doiSerbia

Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives

Peksel Aysegul (Department of Chemistry, Faculty of Arts and Science, Yildiz Technical University, Davutpasa, Istanbul, Turkey)
Celik Cumali (Department of Chemistry, Faculty of Arts and Science, Yildiz Technical University, Davutpasa, Istanbul, Turkey + Community College, Yalova University, Yalova, Turkey)
Ocal Nuket (Department of Chemistry, Faculty of Arts and Science, Yildiz Technical University, Davutpasa, Istanbul, Turkey)
Yanardag Refiye (Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, İstanbul, Turkey)

A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2- picrylhydrazil (DPPH•) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among 11 compounds tested, 7 compounds showed potent reducing power activity and 8 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds had effective antioxidant power.

Keywords: norcantharidin, bridged perhydroisoindole, reducing power, superoxide anion radical