Journal of the Serbian Chemical Society 2022 Volume 87, Issue 7-8, Pages: 829-843
https://doi.org/10.2298/JSC210504019N
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Aspirin-hydrogel ocular film for topical delivery and ophthalmic anti-inflammation
Nanda Ashirbad 
(School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India + Centurion University of Technology and Management, Odisha, India)
Das Shubhashree (Centurion University of Technology and Management, Odisha, India)
Sahoo Rudra N. (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India + Centurion University of Technology and Management, Odisha, India)
Nandi Souvik (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India)
Swain Rakesh (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India)
Pattanaik Sunil (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India)
Das Debajyoti (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India)
Mallick Subrata (School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India), [email protected]; [email protected]
Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. An ophthalmic anti-inflammation study was undertaken using topically applied aspirin in a hydrogel film formulation. A hydroxypropyl methylcellulose (HPMC) matrix film formulation was prepared by the solvent casting and evaporation technique by taking triethanolamine (TEA) as a plasticizer. Ex vivo corneal permeation as well as anti-inflammatory potential of aspirin was studied on carrageenan induced rabbit eye model. Moisture uptake was found to be in the range of 17.1 and 19.1 % for all the film formulations. The film with the higher HPMC content exhibited both increased moisture uptake and amount of swelling. Among the formulations, the swelling order was found to increase with increasing amount of HPMC in the film. Presence of the hydrogel matrix forming polymer sustained the drug release and corneal permeation for more than 6 h and controlled the process by the diffusion mechanism. The signs of carrageenan induced acute inflammation was inhibited completely within just 2 h of placing the film in the rabbit eye whilst the positive control continued showing redness and increased tear secretion. Aspirin ocular film formulation could be utilized for ocular anti-inflammation for an extended period of time with better patient compliance.
Keywords: non-steroidal anti-inflammatory drug, ocular delivery, HPMC, swelling and erosion
Show references
G. Fang, Q. Wang, X. Yang, Y. Qian, G. Zhang, Q. Zhu, B. Tang, Colloids Surfaces,. A 627 (2021) 127187 (https://doi.org/10.1016/j.colsurfa.2021.127187)
G. Fan, G. Li-li, W. Yan-rong, Q.I. Wang, Int. Eye Sci. 17 (2017) 2359 (https://doi.org/10.3980/j.issn.1672-5123.2017.12.45)
M. T. Kralinger, M. Voigt, G. F. Kieselbach, D. Hamasaki, B. C. Hayden, J. M. Parel, Ophthalmic Res. 35 (2003) 102 (https://doi.org/10.1159/000069129)
S. Das, J. R. Bellare, R. Banerjee, Colloids Surfaces, B 93 (2012) 161 (https://doi.org/10.1016/j.colsurfb.2011.12.033)
A. Yazici, E. Sarı, E. Ayhan, J. Ocul. Pharmacol. Ther. 34 (2018) 256 (https://doi.org/10.1089/jop.2017.0064)
Ameeduzzafar, J. Ali, M. Fazil, M. Qumbar, N. Khan, A. Ali, Drug Deliv. 23 (2016) 700 (https://doi.org/10.3109/10717544.2014.923065)
L. Battaglia, M. Gallarate, L. Serpe, F. Foglietta, E. Muntoni, A. P. Rodriguez, M. Angeles, S. Aspiazu, in Lipid Nanocarriers for Drug Targeting, A. M. Grumezescu, Ed., William Andrew Applied Science Publishers, Norwich, NY, 2018, pp. 269-312 (https://doi.org/10.1016/B978-0-12-813687-4.00007-4)
A. Pramanik, R. N. Sahoo, S. K. Pradhan, S. Mallick, Indian J. Pharm. Sci. 83 (2021) 794-807 (https://doi.org/10.36468/pharmaceutical-sciences.831)
R. Swain, S. Nandi, R. N. Sahoo, S. S. Swain, S. Mohapatra, S. Mallick. J. Drug Deliv. Sci. Technol. 67 (2021) 102956 (https://doi.org/10.1016/j.jddst.2021.102956)
Z. Jafariazar, N. Jamalinia, F. Ghorbani-Bidkorbeh, S. A. Mortazavi, Iran. J. Pharm. Sci. 14 (2015) 23 (https://doi.org/10.22037/ijpr.2015.1709)
G. Fang, X. Yang, Q. Wang, A. Zhang, B. Tang, Mater. Sci. Eng., C 127 (2021) 112212 (https://doi.org/10.1016/j.msec.2021.112212)
N. Kavanagh, O. I. Corrigan, Int. J. Pharm. 279 (2004) 141 (https://doi.org/10.1016/j.ijpharm.2004.04.016)
B. Vigani, S. Rossi, G. Sandri, M. C. Bonferoni, C. M. Caramella, F. Ferrari, Pharmaceutics 12 (2020) 859 (https://doi.org/10.3390/pharmaceutics1209085)
A. A. El-Bary, H. K. Ibrahim, B. S. Haza’a, I. A. Sharabi, Pharm. Dev. Technol. 24 (2019) 824 (https://doi.org/10.1080/10837450.2019.1602631)
M. Mansour, S. Mansour, N. D. Mortada, S. S. Abd El-Hady, Drug. Dev. Ind. Pharm. 34 (2008):744 (https://doi.org/10.1080/03639040801926030)
M. Tighsazzadeh, J. C. Mitchell, J. S. Boateng, Int. J. Pharm. 566 (2019) 111 (https://doi.org/10.1016/j.ijpharm.2019.05.059).
J. Ye, H. Zhang, H. Wu, C. Wang, X. Shi, J. Xie, J. He, J. Yang, Graefes Arch. Clin. 250 (2012) 1459 (https://doi.org/10.1007/s00417-012-2087-4)
A. Nanda, R. N. Sahoo, A. Pramanik, Colloids Surfaces, B 172 (2018) 555 (https://doi.org/10.1016/j.colsurfb.2018.09.011)
M. R. Abbaspour, B. S. Makhmalzadeh, S. Jalali, Jundishapur J. Nat. Pharm. Prod. 5 (2010) 6 (https://brief.land/jjnpp/articles/72379.html)
P. Talik, J. Piotrowska, U. Hubicka, AAPS Pharm. Sci. Tech. 20 (2019) 187 (https://doi.org/10.1208/s12249-019-1406-z)
R. Mohapatra, S. Senapati, C. Sahoo, S. Mallick, Colloids Surfaces, B 123 (2014)170 (https://doi.org/10.1016/j.colsurfb.2014.09.012)
A. Pramanik, R. N. Sahoo, A. Nanda, Curr. Eye Res. 43 (2018) 828 (https://doi.org/10.17344/acsi.2019.5139)
K. N. Priya, S. Bhattacharyya, P. R. Babu, Dhaka Univ. J. Pharm. Sci. 13 (2014) 75 (https://doi.org/10.3329/dujps.v13i1.21866)
B. Panda, R. Subhadarsini, S. Mallick, Expert Opin. Drug Deliv. 13 (2016) 633 (https://doi.org/10.1517/17425247.2016.1154038)
M. J. Habib, J. A. Rogers, Int. J. Pharm. 44 (1988) 235 (https://doi.org/10.1016/0378-5173(88)90120-2)
J. T. Mitchell-Koch, K. R. Reid, M. E. Meyerhoff, J. Chem. Educ. 85 (2008) 1658 (https://doi.org/10.1021/ed085p1658)
N. A. Farid, G. S. Born, W. V. Kessler, S. M. Shaw, W. E. Lange, Clin. Chem. 21 (1975) 1167 (https://doi.org/10.1093/clinchem/21.8.1167)
W. J. Keller Jr., Am. J. Clin. Pathol. 17 (1947) 415 (https://doi.org/10.1093/ajcp/17.5_ts.415)
W. A. McBryde, J. L. Rohr, J. S. Penciner, J. A. Page, Can. J. Chem. 48 (1970) 2574 (https://doi.org/10.1139/v70-433)
A. Pramanik, R. N. Sahoo, S. Nandi, A. Nanda, S. Mallick, Acta Chim. Slov. 68 (2021) 159-69 (http://dx.doi.org/10.17344/acsi.2020.6298)
P. W. Morrison, C. J. Connon, V. V. Khutoryanskiy, Mol. Pharm. 10 (2013) 756 (https://doi.org/10.1021/mp3005963)
R. N. Sahoo, B. S. Satapathy, S. Mallick, J. Serb. Chem. Soc. 86 (2021) 571 (https://doi.org/10.2298/JSC201209021N)
B. S. Satapathy, A. Patel, R. N. Sahoo, S. Mallick, J. Serb. Chem. Soc. 86 (2021) 51 (https://doi.org/10.2298/JSC200705049S)
P. K. Pawar, D. K. Majumdar, AAPS Pharm. Sci. Tech. 7 (2006) 13 (https://doi.org/10.1208/pt070113)
M. F. Sohail, G. Shahnaz, F. ur Rehman, A. ur Rehman, N. Ullah, U. Amin, G. M. Khan, K. U. Shah, AAPS Pharm. Sci. Tech. 20 (2019) 288 (https://doi.org/10.1208/s12249-019-1484-y)
S. Nandi, A. Ojha, A. Nanda, R. N. Sahoo, R. Swain, K. P. Pattnaik, S. Mallick, Z. Phys. Chem. 236 (2021) 275 (https://doi.org/10.1515/zpch-2021-3081)
E. Larraneta, R. E. Lutton, A. J. Brady, E. M. Vicente‐Pérez, A. D. Woolfson, R. R. Thakur, R.F. Donnelly, Macromol. Mater. Eng. 300 (2015) 586 (https://doi.org/10.1002/mame.201500016)
A. Semalty, M. Semalty, D. Singh, M. S. Rawat, Int. J. Pharm. Sci. Nanotechnol. 3 (2010) 940 (https://doi.org/10.37285/ijpsn.2010.3.2.7)
S. Farias, J. S. Boateng, Int. J. Pharm. 553 (2018) 65 (https://doi.org/10.1016/j.ijpharm.2018.10.025)
R. Mohanty, S. K. Das, N. R. Singh, M. Patri, Zebrafish. 13 (2016) 188 (https://doi.org/10.1089/zeb.2015.1215)
J. A. Castro-Hermida, H. GóMez-Couso, M. E. Ares-Mazás, M. M. Gonzalez-Bedia, N. CastañEda-Cancio, F. J. Otero-Espinar, J. Blanco-Mendez, J. Pharm. Sci. 93 (2004) 197 (https://doi.org/10.1002/jps.10528)
T. Oka, T. Shearer, M. Azuma, Curr. Eye Res. 29 (2004) 27 (https://doi.org/10.1080/02713680490513164)
J. C. Fehrenbacher, M. R. Vasko, D. B. Duarte, Curr. Protoc. Pharmacol. 56 (2012) 541 (https://doi.org/10.1002/0471141755.ph0504s56).