doiSerbia

Antibacterial properties of thalloid liverworts Marchantia polymorpha L., Conocephalum conicum (L.) Dum. and Pellia endiviifolia (Dicks.) Dumort

Ivković Ivana M. (University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Begrade, Serbia)
Bukvički Danka R. (University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Begrade, Serbia), [email protected]
Novaković Miroslav M. (University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Serbia)
Ivanović Stefan G. (University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Serbia)
Stanojević Olja Ј. (University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Begrade, Serbia)
Nikolić Ivan С. (University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Begrade, Serbia)
Veljić Milan M. (University of Belgrade, Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Begrade, Serbia)

The antimicrobial activity of methanol extracts of three thalloid liverworts, Marchantia polymorpha, Conocephalum conicum and Pellia endiviifolia and bis-bibenzyl marchantin A, the most dominant compound in the methanol extract of M. polymorpha, have been investigated in this research. 1H-NMR spectroscopy revealed that the M. polymorpha and P. endiviifolia extracts of liverwort contain terpenes, oils, sugars and bis-bibenzyls, while these specific macrocyclic compounds were absent in the C. conicum extract. The antimicrobial potential was tested on eight bacterial strains. Antimicrobial effects of extracts and marchantin A were observed against Gram-positive bacteria, while they showed no effect against Gram-negative bacteria in both methods used – well diffusion and broth microdilution.

Keywords: bis-bibenzyls, marchantin A, extracts, antimicrobial activity, 1H NMR

Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 451-03-9/2021-14/200178 and Grant no. 451-03-9/2021-14/200026