The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders
Abstract
:1. Introduction
2. m6A RNA Methylation Mechanism
2.1. m6A Methyltransferase (Writers)
2.2. m6A Demethylases (Erasers)
2.3. m6A Binding Proteins (Readers)
3. m6A Modification Is Involved in the Regulation of Central Nervous System Functions
3.1. m6A Modification and Brain Tissue Development
3.2. m6A Modification and Neural Stem Cell Self-Renewal and Differentiation
3.3. m6A Modification and Neuronal Synapse Formation
3.4. m6A Modification Regulates Learning and Memory
4. m6A Modification in Neuropsychiatric Disorders
4.1. m6A Modification and Glioblastoma
4.2. m6A Modification and Alzheimer’s Disease
4.3. m6A Modification and Parkinson’s Disease
4.4. m6A Modification and Major Depressive Disorder
5. m6A Modifying Enzyme Inhibitors: A Potential Therapeutic Tool
6. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
mRNA | Messenger RNA |
tRNA | Transfer RNA |
rRNA | Ribosomal RNA |
lncRNA | Long non-coding RNA |
SAM | S-adenosylmethionine |
METTL3 | Methyltransferase-like protein 3 |
METTL14 | Methyltransferase-like protein 3 |
WTAP | Wt1 Associated Protein |
KIAA1429 (VIRMA) | Vir Like M6A Methyltransferase Associated |
ZFP217 | Zinc Finger Protein 217 |
RBM15 | RNA Binding Motif Protein 15 |
RBM15B | RNA Binding Motif Protein 15B |
HAKAI | Cbl Proto-Oncogene Like 1 |
ZC3H13 | Zinc Finger Ccch-Type Containing 13 |
FIP37 | FKBP12 interacting protein 37 |
FTO | Fat Mass and Obesity Associated Protein |
ALKBH5 | Alkb Homolog 5, RNA Demethylase |
SGZ | Subgranular zones |
SVZ | Subventricular zone |
GSCs | Glioblastoma stem cells |
SRSF2 | Serine And Arginine Rich Splicing Factor 2 |
RUNX1T1 | Runx1 Partner Transcriptional Co-Repressor 1 |
hnRNP | Heterogeneous Nuclear Ribonucleoprotein |
eIF3 | Eukaryotic Initiation Factor 3 |
YTHDF2 | Yth N6-Methyladenosine RNA Binding Protein 2 |
CNOT1 | Ccr4-Not Transcription Complex Subunit 1 |
SME | Synaptic m6A epitranscriptome |
YTHDF1 | Yth N6-Methyladenosine RNA Binding Protein 1 |
YTHDF3 | Yth N6-Methyladenosine RNA Binding Protein 3 |
YTHDC1 | Yth Domain Containing 1 |
SRSF3 | Serine And Arginine Rich Splicing Factor 3 |
YTHDC2 | Yth Domain Containing 2 |
IGF2BPs | Insulin-Like Growth Factor 2 mRNA-Binding Protein |
RBPs | RNA-Binding Proteins |
IGF2BP1 | Insulin Like Growth Factor 2 mRNA Binding Protein 1 |
IGF2BP2 | Insulin Like Growth Factor 2 mRNA Binding Protein 2 |
IGF2BP3 | Insulin Like Growth Factor 2 mRNA Binding Protein 3 |
MYC | Myc Proto-Oncogene, Bhlh Transcription Factor |
HNRNPC | Heterogeneous Nuclear Ribonucleoprotein C |
HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1 |
HNRNPG | RNA binding motif protein X-linked |
DGCR8 | DGCR8 microprocessor complex subunit |
CNS | Central Nervous System |
AML | Acute myeloid leukemia |
Dapk1 | Death Associated Protein Kinase 1 |
Fadd | Fas Associated Via Death Domain |
Ngfr | Nerve Growth Factor Receptor |
Pdgfra | Platelet derived growth factor receptor alpha |
ADAM19 | A disintegrin and metallopeptidase domain 19 |
TUBB3 | Class III β-tubulin |
CBP/P300 | CREB binding protein |
COL4A1 | Collagen type IV alpha 1 |
GFAP | Glial fibrillary acidic protein |
UBXN1 | UBX domain protein 1 |
HuR | Human antigen R |
SOX2 | Sex-determining region Y-box protein 2 |
Socs5 | Suppressor Of Cytokine Signaling 5 |
GAP-43 | Growth Associated Protein 43 |
APC | Adenomatous Polyposis Coli |
VEGFA | Vascular endothelial growth factor A |
Dvl1 | Dishevelled Segment Polarity Protein 1 |
Wnt5a | Wnt Family Member 5A |
LXRα | Nuclear Receptor Subfamily 1 Group H Member 3 |
HIVEP2 | Hivep Zinc Finger 2 |
FOXM1 | Forkhead Box M1 |
TSC1 | TSC Complex Subunit 1 |
NMDAR1 | Glutamate Ionotropic Receptor Nmda Type Subunit 1 |
FAAH | Fatty Acid Amide Hydrolase |
Adrb2 | Adrenoceptor beta 2 |
p-CaMKII | Phospho-Calcium/Calmodulin Dependent Protein Kinase II Gamma |
p-CREB | Phospho-Camp Responsive Element Binding Protein 1 |
MA | Meclofenamic acid |
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Lei, C.; Wang, Q. The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders. Int. J. Mol. Sci. 2022, 23, 5922. https://doi.org/10.3390/ijms23115922
Lei C, Wang Q. The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders. International Journal of Molecular Sciences. 2022; 23(11):5922. https://doi.org/10.3390/ijms23115922
Chicago/Turabian StyleLei, Chunguang, and Qingzhong Wang. 2022. "The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders" International Journal of Molecular Sciences 23, no. 11: 5922. https://doi.org/10.3390/ijms23115922