Glycans are remodeled by HIV and are determinants of CD4+ T cell susceptibility to HIV infection.

An in-depth view of the in vivo blood and tissue HIV reservoir is presented highlighting shared phenotypic features between individuals, thus enabling marked ex vivo enrichment of replication-competent latent cells.

ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.

CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.

CD4+ T cells from the female reproductive tract are unusually susceptible to HIV infection and are altered by HIV in ways that promote survival and systemic spread of the virus.

Together, our multi-tissue single-cell data shows that CD56^bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.

COVID-19 mRNA vaccine-elicited T cells recognize variants of concern and phenotypically differ depending on number of vaccine doses and prior SARS-CoV-2 infection status.

In localized autoimmune disease, there is autoantigen-driven expansion of both effector T cell and Treg clones that are highly persistent and are (re)circulating, and might represent interesting therapeutic targets.

The macaque monkey intraparietal sulcus encompasses 17 cyto- and receptorarchitectonically distinct areas, which can be grouped into three clusters based on (dis)similarities of their molecular structure.

ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.