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Chemical compound
Adimolol ATC code
3-[3-[[2-hydroxy-3-(1-naphthyloxy)propyl]amino]-3-methyl-butyl]-1H -benzimidazol-2-one
CAS Number Formula C 25 H 29 N 3 O 3 Molar mass 419.525 g·mol−1 3D model (JSmol )
O=C2Nc1ccccc1N2CCC(NCC(O)COc4c3ccccc3ccc4)(C)C
InChI=1S/C25H29N3O3/c1-25(2,14-15-28-22-12-6-5-11-21(22)27-24(28)30)26-16-19(29)17-31-23-13-7-9-18-8-3-4-10-20(18)23/h3-13,19,26,29H,14-17H2,1-2H3,(H,27,30)
Y Key:YWRIUGFSIQMHJK-UHFFFAOYSA-N
Y
N Y (what is this?) (verify)
Adimolol (developmental code name MEN-935 ) is antihypertensive agent which acts as a non-selective α1 - , α2 - , and β-adrenergic receptor antagonist .[ 1]
The reaction between 1-naphthyl glycidyl ether (1 ) and 3-(3-amino-3-methylbutyl)-1H -benzimidazol-2-one (2 ) gives adimolol (3 ).[ 2] [ 3]
Synthesis of adimolol
^ Palluk R, Hoefke W, Gaida W, Mierau J, Bechtel WD (July 1986). "Interactions of MEN 935 (adimolol), a long acting beta- and alpha-adrenolytic antihypertensive agent, with postsynaptic alpha-adrenoceptors in different isolated blood vessels--influence of angiotensin II". Naunyn-Schmiedeberg's Archives of Pharmacology . 333 (3): 277–83. doi :10.1007/bf00512941 . PMID 3020439 . S2CID 24300936 .
^ Hoefke W, Gaida W, Palluk R, Mentrup A (1986). "Adimolol Hydrochloride Hydrate". Drugs of the Future . 11 : 9. doi :10.1358/dof.1986.011.01.62036 .
^ US 4255430 , Koppe H, Mentrup A, Renth EO, Schromm K, Hoefke W, Muacevic G, issued 1981, assigned to Boehringer Ingelheim Gmbh
α1
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Abanoquil
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Urapidil
WB-4101
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1-PP
Adimolol
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Sunepitron
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Tolazoline
Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
Yohimbine
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