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Chemical compound
Ciclotizolam ATC code Legal status
8-bromo-6-(o -chlorophenyl)-1-cyclohexyl-4H -5-triazolo(3,4-c )thieno(2,4-e )-1,4-diazepine
CAS Number Formula C 20 H 18 Br Cl N 4 S Molar mass 461.81 g·mol−1 3D model (JSmol )
Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4
InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2
Y Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N
Y
N Y (what is this?) (verify)
Ciclotizolam [1] (WE-973 ) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor , with similar binding affinity to related compounds like brotizolam , but a low efficacy .[2] [3]
See also [ edit ]
References [ edit ]
^ DE Patent 2445430
^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology . 109 (1): 19–31. doi :10.1016/0014-2999(85)90535-7 . PMID 2986988 .
^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences . 45 (4): 349–58. doi :10.1016/0024-3205(89)90145-8 . PMID 2569655 .
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