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Protein-coding gene in the species Homo sapiens
Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene .
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Function [ edit ]
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
References [ edit ]
Further reading [ edit ]
Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun . 296 (2): 343–9. doi :10.1016/s0006-291x(02)00862-8 . PMID 12163023 .
Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J (2003). "Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor" . J. Biol. Chem . 278 (33): 30772–80. doi :10.1074/jbc.M304982200 . PMID 12788921 .
Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J (2004). "The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues" . J. Biol. Chem . 279 (50): 52255–61. doi :10.1074/jbc.M410007200 . PMID 15456751 .
Hirota K, Semenza GL (2005). "Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases" . Biochem. Biophys. Res. Commun . 338 (1): 610–6. doi :10.1016/j.bbrc.2005.08.193 . PMID 16154531 .
Iwahashi M, Muragaki Y, Ino K (2012). "Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle" . Reprod. Biol. Endocrinol . 10 : 111. doi :10.1186/1477-7827-10-111 . PMC 3566935 . PMID 23241241 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .