Talk:Fragment antigen-binding region

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Molecular Biology: MCB

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Prime

What does the prime symbol in “Fab′” stand for? Palpalpalpal (talk) 12:17, 4 June 2010 (UTC)[reply]

Fab stands for Fragment antigen-binding which is a portion of the antibody in which the antigen is bound. It is distinquished from the Fc portion —Preceding unsigned comment added by 216.169.216.1 (talk) 17:21, 30 June 2010 (UTC)[reply]

Thanks, but this does not seem to address my question. I’m not asking about the acronym, but specifically about the prime symbol: what’s the difference between “Fab” and “Fab′”? Palpalpalpal (talk) 21:15, 7 August 2012 (UTC)[reply]

This was asked a while ago, but hasn't been answered so I'll leave this here for reference: F(ab')2 is the 'Fab' formed when pepsin is used to cleave it, so it includes the disulfide bonds (the two sides are connected together) - have a look at the two images to the right on the page. I think the prime just suggests it's a variant. --Goldensharpshot (talk) 11:41, 14 March 2014 (UTC)[reply]