Terlipressin
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Clinical data | |
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Trade names | Terlivaz |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Intravenous |
ATC code | |
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Pharmacokinetic data | |
Protein binding | ~30% |
Identifiers | |
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CAS Number | |
ECHA InfoCard | 100.035.149 |
Chemical and physical data | |
Formula | C52H74N16O15S2 |
Molar mass | 1227.38 g·mol−1 |
3D model (JSmol) | |
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Terlipressin, sold under the brand name Terlivaz among others, is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help. Terlipressin is a vasopressin receptor agonist.[2]
Terlipressin was approved for medical use in the United States in 2022.[2][4][5] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[5][6]
Medical uses[edit]
Terlipressin is indicated to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function.[2]
Indications for use include norepinephrine-resistant septic shock[7] although, 2021 Surviving Sepsis Guidelines recommend against its use for adults with septic shock[8] and hepatorenal syndrome.[9] In addition, it is used to treat bleeding esophageal varices.[10]
Contraindications[edit]
Terlipressin is contraindicated in people experiencing hypoxia or worsening respiratory symptoms and in people with ongoing coronary, peripheral or mesenteric ischemia.[2] Terlipressin may cause fetal harm when used during pregnancy.[2]
Society and culture[edit]
Terlipressin is available in United States,[11] New Zealand,[12] Australia, the European Union,[13] India, Pakistan & UAE. It is sold under various brand names including Glypressin and Terlivaz.
References[edit]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ a b c d e f "Terlivaz- terlipressin injection, powder, lyophilized, for solution". DailyMed. 19 September 2022. Archived from the original on 28 September 2022. Retrieved 27 September 2022.
- ^ "Drug Approval Package: Terlivaz". U.S. Food and Drug Administration (FDA). 7 October 2022. Retrieved 4 December 2022.
- ^ "Drug Approval Package: Terlivaz". U.S. Food and Drug Administration (FDA). 7 October 2022. Retrieved 23 January 2023.
- ^ a b This article incorporates text from this source, which is in the public domain.
- ^ This article incorporates text from this source, which is in the public domain.
- ^ O'Brien A, Clapp L, Singer M (April 2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209–1210. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542. S2CID 38463837.
- ^ Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. (November 2021). "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021". Critical Care Medicine. 49 (11): e1063–e1143. doi:10.1097/CCM.0000000000005337. PMID 34605781.
- ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón JM, et al. (July 2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". Journal of Hepatology. 33 (1): 43–48. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585.
- ^ Ioannou G, Doust J, Rockey DC (2003). Ioannou GN (ed.). "Terlipressin for acute esophageal variceal hemorrhage". The Cochrane Database of Systematic Reviews (1): CD002147. doi:10.1002/14651858.CD002147. PMC 7017851. PMID 12535432.
- ^ "FDA approves treatment to improve kidney function in adults with hepatorenal syndrome". FDA. 14 September 2022. Archived from the original on 2023-02-10. Retrieved 2023-02-21.
- ^ "GLYPRESSIN 1mg/8.5mL Solution for Injection; Terlipressin acetate" (PDF). Medsafe, New Zealand Medicines and Medical Devices Safety Authority. New Zeeland Ministry of Health. Archived from the original (PDF) on 2021-12-20.
- ^ "Terlipressin". Drugs.com. Archived from the original on 2019-06-26. Retrieved 2018-01-23.
External links[edit]
- "Terlipressin". Drug Information Portal. U.S. National Library of Medicine.