Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands'

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Published online 2014 Jun 4. doi: 10.1038/ejhg.2014.19

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Table 1

Mean observed r² of rare variants

Reference set	Dutch	British	Italian
1000G	0.61	0.58	0.43
GoNL	0.71	0.65	0.47
1000G+GoNL	0.72	0.67	0.50

Abbreviation: GoNL, The Genome of The Netherlands.

Differences in the mean imputation quality between the reference sets was significant for each population (P<0.001).