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Reviews/Commentary:

A public gene trap resource for mouse functional genomics.
Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J, International Gene Trap Consortium
Nat Genet. 2004 Jun;36(6):543-4. PMID: 15167922

Gene-trap mutagenesis: past, present and beyond.
Stanford WL, Cohn JB, Cordes SP
Nat Rev Genet. 2001 Oct;2(10):756-68. PMID: 11584292

Mouse mutagenesis on target.
Jackson IJ
Nat Genet. 2001 Jul;28(3):198-200. PMID: 11431680

Sequence interpretation. Functional annotation of mouse genome sequences.
Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A, International Mouse Mutagenesis Consortium
Science. 2001 Feb 16;291(5507):1251-5. PMID: 11233449

Gene Trap Resources:

The Centre for Modeling Human Disease Gene Trap resource.
To C, Epp T, Reid T, Lan Q, Yu M, Li CY, Ohishi M, Hant P, Tsao N, Casallo G, Rossant J, Osborne LR, Stanford WL
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D557-9. PMID: 14681480

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003 Jan 1;31(1):278-81. PMID: 12520002

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.
Wiles MV, Vauti F, Otte J, Fuchtbauer EM, Ruiz P, Fuchtbauer A, Arnold HH, Lehrach H, Metz T, von Melchner H, Wurst W
Nat Genet. 2000 Jan;24(1):13-4. PMID: 10615117

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.
Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT
Nature. 1998 Apr 9;392(6676):608-11. PMID: 9560157

Functional genomics in mice by tagged sequence mutagenesis.
Hicks GG, Shi EG, Li XM, Li CH, Pawlak M, Ruley HE
Nat Genet. 1997 Aug;16(4):338-44. PMID: 9241269

Methods Chapters:

Gene trap mutagenesis in embryonic stem cells.
Chen WV, Soriano P
Methods Enzymol. 2003;365():367-86. PMID: 14696359

Gene trapping methods for the identification and functional analysis of cell surface proteins in mice.
Skarnes WC
Methods Enzymol. 2000;328():592-615. PMID: 11075368

Gene trapping in mouse embryonic stem cells.
Brennan J, Skarnes WC
Methods Mol Biol. 1999;97():123-38. PMID: 10443362

Screening for novel pattern formation genes using gene trap approaches.
Hill DP, Wurst W
Methods Enzymol. 1993;225():664-81. PMID: 8231878

Gene Trapping Approaches:

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-betageo cassette.
Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T, Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K, Araki K
Dev Growth Differ. 2005 Apr;47(3):163-72. PMID: 15840001

Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis.
Chen WV, Delrow J, Corrin PD, Frazier JP, Soriano P
Nat Genet. 2004 Mar;36(3):304-12. PMID: 14981515

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. PMID: 14610273

Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques.
Yin Y, Kikkawa Y, Mudd JL, Skarnes WC, Sanes JR, Miner JH
Genesis. 2003 Jun;36(2):114-27. PMID: 12820173

Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites.
Araki K, Araki M, Yamamura K
Nucleic Acids Res. 2002 Oct 1;30(19):e103. PMID: 12364620

Genomewide trapping of genes that encode secreted and transmembrane proteins repressed by oncogenic signaling.
Gebauer M, von Melchner H, Beckers T
Genome Res. 2001 Nov;11(11):1871-7. PMID: 11691852

Functional analysis of secreted and transmembrane proteins critical to mouse development.
Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes WC
Nat Genet. 2001 Jul;28(3):241-9. PMID: 11431694

A gene trap vector system for identifying transcriptionally responsive genes.
Medico E, Gambarotta G, Gentile A, Comoglio PM, Soriano P
Nat Biotechnol. 2001 Jun;19(6):579-82. PMID: 11385465

Defining brain wiring patterns and mechanisms through gene trapping in mice.
Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M
Nature. 2001 Mar 8;410(6825):174-9. PMID: 11242070

Gene trapping identifies transiently induced survival genes during programmed cell death.
Wempe F, Yang JY, Hammann J, von Melchner H
Genome Biol. 2001;2(7):RESEARCH0023. PMID: 11516336

An induction gene trap for identifying a homeoprotein-regulated locus.
Mainguy G, Montesinos ML, Lesaffre B, Zevnik B, Karasawa M, Kothary R, Wurst W, Prochiantz A, Volovitch M
Nat Biotechnol. 2000 Jul;18(7):746-9. PMID: 10888842

Exchangeable gene trap using the Cre/mutated lox system.
Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K
Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50. PMID: 10512203

Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma.
Wallace MJ, Batt J, Fladd CA, Henderson JT, Skarnes W, Rotin D
Nat Genet. 1999 Mar;21(3):334-8. PMID: 10080192

Capturing novel mouse genes encoding chromosomal and other nuclear proteins.
Tate P, Lee M, Tweedie S, Skarnes WC, Bickmore WA
J Cell Sci. 1998 Sep;111 ( Pt 17)():2575-85. PMID: 9701556

Disruption of genes regulated during hematopoietic differentiation of mouse embryonic stem cells.
Muth K, Bruyns R, Thorey IS, von Melchner H
Dev Dyn. 1998 Jun;212(2):277-83. PMID: 9626502

Selective disruption of genes transiently induced in differentiating mouse embryonic stem cells by using gene trap mutagenesis and site-specific recombination.
Thorey IS, Muth K, Russ AP, Otte J, Reffelmann A, von Melchner H
Mol Cell Biol. 1998 May;18(5):3081-8. PMID: 9566926

Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice.
Townley DJ, Avery BJ, Rosen B, Skarnes WC
Genome Res. 1997 Mar;7(3):293-8. PMID: 9074932

Targeted integration of DNA using mutant lox sites in embryonic stem cells.
Araki K, Araki M, Yamamura K
Nucleic Acids Res. 1997 Feb 15;25(4):868-72. PMID: 9016639

Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific recombination.
Russ AP, Friedel C, Ballas K, Kalina U, Zahn D, Strebhardt K, von Melchner H
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15279-84. PMID: 8986802

An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Forrester LM, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, Joyner AL, Wurst W
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1677-82. PMID: 8643689

Capturing genes encoding membrane and secreted proteins important for mouse development.
Skarnes WC, Moss JE, Hurtley SM, Beddington RS
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6. PMID: 7604039

The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation.
Wilson V, Manson L, Skarnes WC, Beddington RS
Development. 1995 Mar;121(3):877-86. PMID: 7720590

A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.
Wurst W, Rossant J, Prideaux V, Kownacka M, Joyner A, Hill DP, Guillemot F, Gasca S, Cado D, Auerbach A
Genetics. 1995 Feb;139(2):889-99. PMID: 7713439

An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events.
Niwa H, Araki K, Kimura S, Taniguchi S, Wakasugi S, Yamamura K
J Biochem (Tokyo). 1993 Mar;113(3):343-9. PMID: 8387481

Fluorescence-activated sorting of totipotent embryonic stem cells expressing developmentally regulated lacZ fusion genes.
Reddy S, Rayburn H, von Melchner H, Ruley HE
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6721-5. PMID: 1495960

A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.
Skarnes WC, Auerbach BA, Joyner AL
Genes Dev. 1992 Jun;6(6):903-18. PMID: 1592261

Selective disruption of genes expressed in totipotent embryonal stem cells.
von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE
Genes Dev. 1992 Jun;6(6):919-27. PMID: 1317320

Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells.
Reddy S, DeGregori JV, von Melchner H, Ruley HE
J Virol. 1991 Mar;65(3):1507-15. PMID: 1704929

Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.
Gossler A, Joyner AL, Rossant J, Skarnes WC
Science. 1989 Apr 28;244(4903):463-5. PMID: 2497519

Mutant Screens in Mice:

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Fuchtbauer EM, Vauti F, Arnold HH, Schnutgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. PMID: 12904583

Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system.
Stoykova A, Chowdhury K, Bonaldo P, Torres M, Gruss P
Dev Dyn. 1998 Jun;212(2):198-213. PMID: 9626495

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
Friedrich G, Soriano P
Genes Dev. 1991 Sep;5(9):1513-23. PMID: 1653172

Mouse Mutants:

Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.
Miyata K, Oike Y, Hoshii T, Maekawa H, Ogawa H, Suda T, Araki K, Yamamura K
Biochem Biophys Res Commun. 2005 Apr 1;329(1):296-304. PMID: 15721306

Serine-arginine-rich nuclear protein Luc7l regulates myogenesis in mice.
Kimura E, Hidaka K, Kida Y, Morisaki H, Shirai M, Araki K, Suzuki M, Yamamura KI, Morisaki T
Gene. 2004 Oct 27;341():41-7. PMID: 15474286

ATP-citrate lyase deficiency in the mouse.
Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG
J Biol Chem. 2004 Mar 5;279(10):9557-64. PMID: 14662765

Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.
Tzouanacou E, Tweedie S, Wilson V
Mol Cell Biol. 2003 Dec;23(23):8553-2. PMID: 14612400

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.
Charalambous M, Smith FM, Bennett WR, Crew TE, Mackenzie F, Ward A
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8292-7. PMID: 12829789

Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells.
Senju S, Hirata S, Matsuyoshi H, Masuda M, Uemura Y, Araki K, Yamamura K, Nishimura Y
Blood. 2003 May 1;101(9):3501-8. PMID: 12406878

Defining the importance of phosphatidylserine synthase 2 in mice.
Bergo MO, Gavino BJ, Steenbergen R, Sturbois B, Parlow AF, Sanan DA, Skarnes WC, Vance JE, Young SG
J Biol Chem. 2002 Dec 6;277(49):47701-8. PMID: 12361952

Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice.
Schymeinsky J, Nedbal S, Miosge N, Poschl E, Rao C, Beier DR, Skarnes WC, Timpl R, Bader BL
Mol Cell Biol. 2002 Oct;22(19):6820-30. PMID: 12215539

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.
Rantanen M, Palmen T, Patari A, Ahola H, Lehtonen S, Astrom E, Floss T, Vauti F, Wurst W, Ruiz P, Kerjaschki D, Holthofer H
J Am Soc Nephrol. 2002 Jun;13(6):1586-94. PMID: 12039988

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.
Houzelstein D, Bullock SL, Lynch DE, Grigorieva EF, Wilson VA, Beddington RS
Mol Cell Biol. 2002 Jun;22(11):3794-802. PMID: 11997514

Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists.
Dionne MS, Skarnes WC, Harland RM
Mol Cell Biol. 2001 Jan;21(2):636-43. PMID: 11134349

Agrin isoforms with distinct amino termini: differential expression, localization, and function.
Burgess RW, Skarnes WC, Sanes JR
J Cell Biol. 2000 Oct 2;151(1):41-52. PMID: 11018052

An LDL-receptor-related protein mediates Wnt signalling in mice.
Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC
Nature. 2000 Sep 28;407(6803):535-8. PMID: 11029008

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development.
Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S
Dev Biol. 2000 Sep 1;225(1):179-87. PMID: 10964473

Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.
Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ, Lowenstein DH, Skarnes WC, Chedotal A, Tessier-Lavigne M
Neuron. 2000 Jan;25(1):43-56. PMID: 10707971

Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis.
Oike Y, Takakura N, Hata A, Kaname T, Akizuki M, Yamaguchi Y, Yasue H, Araki K, Yamamura K, Suda T
Blood. 1999 May 1;93(9):2771-9. PMID: 10216070

Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism.
Oike Y, Hata A, Mamiya T, Kaname T, Noda Y, Suzuki M, Yasue H, Nabeshima T, Araki K, Yamamura K
Hum Mol Genet. 1999 Mar;8(3):387-96. PMID: 9949198

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase.
Bullock SL, Fletcher JM, Beddington RS, Wilson VA
Genes Dev. 1998 Jun 15;12(12):1894-906. PMID: 9637690

Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation.
Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM
J Neurosci Res. 1997 Feb 1;47(3):348-60. PMID: 9039657

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.
Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M
Cell. 1996 Dec 13;87(6):1001-14. PMID: 8978605