Papers by Alessandro Russo
Diabetes Research and Clinical Practice, 2013
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Jan 3, 2016
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Jan 2, 2016
The aim of this study is to identify factors associated with mortality in ICU patients with KPC-K... more The aim of this study is to identify factors associated with mortality in ICU patients with KPC-Kp septic shock. A retrospective analysis of ICU patients with KPC-Kp infection and septic shock observed in a large teaching hospital from November 2010 to December 2014 was performed. A total of 111 patients were included in the study. The most frequent source of infection was unknown focus bacteremia in 53 (47.7%) patients. The rate of resistance to colistin was 51.3%; 30-day mortality was reported for 44 (39.6%) patients. Surviving patients were more frequently treated with an initial therapy (within 24 hours) including ≥2 antibiotics displaying in vitro activity against the isolated KPC-Kp strain (41.8% Vs 18.1%, p=0.01), and were also more likely to receive a definitive therapy including ≥2 in vitro active antibiotics (85.1% Vs 15.9%, p<0.001). Cox regression analysis revealed that a colistin-containing antibiotic regimen (Hazard ratio [HR] 0.21, CI 95% 0.05-0.72, p<0.001), us...
Infectious Disease Reports, 2015
Intensive Care Medicine, 2015
Infectious disease reports, Jan 11, 2015
Gram-positive cocci are emerging causes of spontaneous bacterial peritonitis (SBP), especially in... more Gram-positive cocci are emerging causes of spontaneous bacterial peritonitis (SBP), especially in patients with healthcare-associated infections. We report the case of a 68-year-old man with hepatitis C virus and alcohol-related cirrhosis who developed SBP due to methicillin-resistant Staphylococcus aureus treated with daptomycin. We discuss the potential role of daptomycin in this setting with a review of the literature about the use of daptomycin in primary or secondary bacterial peritonitis.
Antimicrobial agents and chemotherapy, Jan 19, 2015
To determine the incidence, risk factors, and outcomes of bloodstream infections (BSI) subsequent... more To determine the incidence, risk factors, and outcomes of bloodstream infections (BSI) subsequent to Clostridium difficile infection (CDI). Retrospective study of all patients with definite diagnosis of CDI admitted from January 2014 to December 2014 in two large Hospitals in Rome. Two groups of patients were analyzed: those with CDI and subsequent BSI (CDI/BSI+), and those with CDI and no evidence of primary BSI (CDI/BSI-). Data about clinical features, microbiology, treatments and mortality were obtained. Overall, 393 cases of CDI were included in the final analysis: 72 developed a primary nosocomial BSI while 321 had CDI without microbiological and clinical evidence of BSI. Etiologic agents of BSI were Candida species (47.3%), Enterobacteriaceae (19.4%), enterococci (13.9%), and mixed infections (19.4%). In multivariate analysis ribotype 027 (odds ratio [OR] 6.5), CDI recurrence (OR 5.5), severe CDI infection (OR 8.3), and oral vancomycin >500 mg/day (OR 3.1) were recognized a...
Internal and Emergency Medicine
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Jan 14, 2015
The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) ma... more The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.
Journal of Chemotherapy, 2010
Journal of Chemotherapy, 2011
Clinical Infectious Diseases, 2014
Clinical Infectious Diseases, 2013
The American Journal of Cardiology, 2015
Journal of Infection and Chemotherapy, 2013
Journal of Chemotherapy, 2012
Clinical Infectious Diseases, 2013
PloS one, 2015
The diffusion of multidrug-resistant (MDR) bacteria has created the need to identify risk factors... more The diffusion of multidrug-resistant (MDR) bacteria has created the need to identify risk factors for acquiring resistant pathogens in patients living in the community. To analyze clinical features of patients with community-onset pneumonia due to MDR pathogens, to evaluate performance of existing scoring tools and to develop a bedside risk score for an early identification of these patients in the Emergency Department. This was an open, observational, prospective study of consecutive patients with pneumonia, coming from the community, from January 2011 to January 2013. The new score was validated on an external cohort of 929 patients with pneumonia admitted in internal medicine departments participating at a multicenter prospective study in Spain. A total of 900 patients were included in the study. The final logistic regression model consisted of four variables: 1) one risk factor for HCAP, 2) bilateral pulmonary infiltration, 3) the presence of pleural effusion, and 4) the severit...
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Papers by Alessandro Russo