International journal of clinical and experimental medicine, 2015
The aim of this study is to assess clinical outcomes of 23-gauge vitrectomy and silicone oil (SO)... more The aim of this study is to assess clinical outcomes of 23-gauge vitrectomy and silicone oil (SO) tamponade combined with and without phacoemulsification (PE) in rhegmatogenous retinal detachment (RRD). The study included forty eyes of 40 patients that underwent 23-gauge vitrectomy and SO tamponade combined with and without PE. Twenty eyes of 20 cases, of whom underwent 23-gauge vitrectomy and SO tamponade combined with PE were allocated to the group 1. Likewise, 20 eyes of 20 cases that underwent 23-gauge vitrectomy and SO tamponade alone were allocated to the group 2. Best corrected visual acuity (BCVA) between two groups was compared. There was no significant difference in BCVA between the two groups during the 6 months (P = 0.3). Recurrent retinal detachments were observed in 2 cases (10%) in both groups. There was no statistically significant difference between two groups as a point of recurrent retinal detachments (P = 1). We have found higher rates of post-vitrectomy cataract...
Purpose: To assess orbital color Doppler ultrasonography (CDU) parameters of patients with manife... more Purpose: To assess orbital color Doppler ultrasonography (CDU) parameters of patients with manifest hyperopia in comparison to the emmetropes Methods: Forty eyes of 40 patients presenting with manifest hyperopia were included into the study. Forty eyes of 40 emmetropes healthy volunteers also were examined as the control group. We have evaluated ophthalmic artery (OA), central retinal artery (CRA), posterior ciliary artery, central retinal vein (CRV), and superior ophthalmic vein (SOV) flow velocities and resistance indices (RI). Results: RI value in the OA and mean velocities (MV) in the SOV were significantly higher in the group of manifest hyperopia. CDU parameters of the CRA, CRV, nasal and temporal posterior ciliary artery (nPCA, tPCA)) between hyperopic group and the control group were statistically insignificant. Conclusion: Doppler ultrasonography findings revealed that some orbital CDU parameters are altered in eyes with manifest hyperopia compared to emmetropia. Particular...
AIM: To compare the tear functions and the impression cytology scores of the patients with primar... more AIM: To compare the tear functions and the impression cytology scores of the patients with primary open angle glaucoma (POAG), ocular hypertension (OHT) and normal subjects with healthy ocular surface both functionally and clinically. METHODS: Eleven eyes of 11 patients with POAG (mean age: 62. 7 ± 6. 1y), 12 eyes of 12 patients (mean age: 62. 8 ± 6. 4y) with OHT and 12 eyes of 12 normal subjects (mean age: 62. 9 ± 6. 03y) were included to this prospective study. The patients with POAG and OHT had been recently diagnosed with these diseases and none of them had taken anti - glaucoma treatment before. In addition to conjunctival impression cytology, tear break-up time (TBUT) and basal Schirmer’s tests (BST) were performed. Impression cytology specimens of each group were graded and scored in the range of 0-3 according to Nelson’s method. Kruskal - Wallis analysis and Dunn’s multiple comparison tests were used for statistical analysis. RESULTS: The mean BST values were 10.4±1.3, 10.9±...
To examine the integrity of the ocular surfaces of subjects with and without diabetes with no con... more To examine the integrity of the ocular surfaces of subjects with and without diabetes with no conjunctival and dry eye signs and symptoms and compare conjunctival impression cytology findings in diabetics with non-proliferative and proliferative diabetic retinopathy. Conjunctival impression cytology was performed on 43 eyes of 43 subjects with non-proliferative diabetic retinopathy (NPDR), 42 eyes of 42 subjects with proliferative diabetic retinopathy (PDR), and 30 eyes of 30 control subjects. Impression cytology specimens of each group were graded and scored in the range 0-3 according to Nelson's method. There were 45 (52.9%) women and 40 (47.1%) men. The mean age of the patients was 59.6±9.3y (range, 43-76y) in NPDR group and 58.0±8.8y (range, 41-85y) in PDR group. Cases with NPDR and PDR showed statistically significant higher impression cytology scores than control group (P<0.05). There was no difference between the NPDR and PDR patients for impression cytology grading sc...
PurposeTo search subclinical platelet activation via detecting three important platelet activatio... more PurposeTo search subclinical platelet activation via detecting three important platelet activation parameters; mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in diabetic retinopathy (DR) in comparison with those in healthy adults as controls.MethodsThis prospective study included 140 patients who were followed-up at the Ankara Ulucanlar Eye Education and Research Hospital, and 40 normal subjects. All patients and control subjects underwent complete ophthalmologic evaluation. Of patients with type 2 diabetes, 43 cases with diabetes mellitus (DM) have no DR (Group 1), 45 cases with DM have nonproliferative DR (NPDR) (Group 2), and 52 cases with DM have proliferative DR (PDR) (Group 3). In addition, 40 age- and sex-matched healthy controls (Group 4) were included into the study. MPV, PDW, and PCT were measured in the studied groups.ResultsThe MPV levels were significantly altered in Group 1, Group 2, and Group 3 patients when compared with those in the controls (P&lt;0.05), whereas PDW and PCT levels were not significantly changed among groups (P&gt;0.05).ConclusionThe data provided a significant association between MPV levels and DM. Diabetic patients have increased MPV values compared with healthy subjects, but MPV levels were not altered together with the DR stage. Diabetic and DR patients have no different PDW and PCT values compared with healthy subjects. MPV may be a clue for the reflection of subclinical platelet activation in DM regardless of the DR stage.
To analyze the surgical outcomes and retinal redetachment frequency after silicone oil (SO) remov... more To analyze the surgical outcomes and retinal redetachment frequency after silicone oil (SO) removal for complex retinal detachment. This institutional-based study included 894 consecutive patients who underwent pars plana vitrectomy with SO endotamponade for complicated retinal detachment. The effects of preoperative best-corrected visual acuity, vitreous base shaving, intraoperative scleral buckling, retinectomy, SO viscosity, duration of SO, and vitreous hemorrhage at the first postoperative week on the risk of redetachment were investigated. During a mean follow-up of 39.9 months, anatomical success was not achieved in 118 patients (13.2%) after SO removal. On multivariate analysis, risk factors for recurrent retinal detachment included giant retinal tear (adjusted odds ratio [aOR], 12.39; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), high myopia (aOR, 2.70; P = 0.011), surgeries without scleral buckling (aOR, 1.97; P = 0.039), inadequate vitreous base shaving (aOR, 117.62; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), and vitreous hemorrhage at the first postoperative week (aOR, 12.13; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Retinal detachment etiology, inadequate vitreous base shaving, lack of intraoperative scleral buckling, and vitreous hemorrhage at the first postoperative week after SO removal were significant risk factors for retinal redetachment after SO removal, but preoperative visual acuity, SO viscosity, and duration of SO had no significant effect on redetachment.
to describe the demographic characteristics and ocular manifestations of patients with late-onset... more to describe the demographic characteristics and ocular manifestations of patients with late-onset Behçet disease (BD). The patients for this retrospective study were selected using the data obtained from the medical records of 16 patients with late-onset BD between January 2000 and May 2008. twelve (75%) of the cases were male and 4 (25%) were female. The mean age of patients was 53.8 ± 2.9 years (range, 51-60 years). The mean follow-up period was 4.3 ± 1.1 years (range, 3-8 years). Throughout the follow-up period, panuveitis, posterior uveitis, and anterior uveitis were detected in 11 (68.7%), 4 (25%) and 1 (6.2%) of 16 patients, respectively. in our series, the most frequent type of uveitis was panuveitis and male sex seems to be a significant risk factor for developing panuveitis. Late-onset BD showed a marked preponderance of males with a sex ratio of 3:1.
To investigate the electron microscopic findings of the anterior lens capsule in vitrectomized ey... more To investigate the electron microscopic findings of the anterior lens capsule in vitrectomized eyes with silicone oil tamponade. Ten eyes of 10 consecutive patients aged 39 to 74 years who had cataract surgery combined with silicone oil removal from December 2006 to May 2009 were included in the study. The control group included 10 patients with cataract extraction and intraocular lens implantation without history of systemic or other ocular disease. All anterior capsules underwent electron microscopic examination of the anterior lens capsule. During the capsulorhexis, the anterior lens capsule was removed. In the silicone oil tamponade group, silicone oil droplets were detected on the posterior surface of the anterior lens capsule in 5 cases (50%) and surface irregularities, pits, and depressions were present in the posterior surface of the anterior lens capsules in all cases. Silicone oil droplets may infiltrate the lens capsule, especially in diabetic patients. Surface irregularities may be associated with posterior fibrous pseudometaplasia produced by lens epithelial cells under the anterior lens capsule.
To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diab... more To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Vitreous samples were collected from 69 eyes of 69 patients with traumatic lens dislocation (n = 10), grade B PVR with rhegmatogenous retinal detachment (n = 13), grade C PVR with rhegmatogenous retinal detachment (n = 14), PDR with vitreous hemorrhage (n = 18), and PDR with vitreous hemorrhage and tractional retinal detachment (n = 14). Vitreous fluid samples were obtained at vitrectomy, and the levels of VEGF were measured by enzyme-linked immunosorbent assay. The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. Vitreous VEGF concentrations were significantly higher in the patients with grade C PVR, PDR with vitreous hemorrhage and PDR with vitreous hemorrhage and tractional retinal detachment in comparison to the control patients (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). A significant alteration was not observed in patients with grade B PVR (p = 0.55). Vitreous VEGF concentrations are increased in PDR and grade C PVR. The high VEGF concentrations could suggest a possible effect of VEGF on advanced PVR.
We investigated a healthy population of men from different regions of Turkey for the presence of ... more We investigated a healthy population of men from different regions of Turkey for the presence of congenital red-green color blindness. Using Ishihara pseudoisochromatic plates, 941 healthy men from the Turkish army were tested for congenital red-green color blindness. The prevalence of red-green color blindness was 7.33 +/- 0.98% (5.10% protans and 2.23% deutans). These ratios were higher than other reported samples from Mediterranean Europe. Higher percentages of color blindness were found in regions with a lower education level and more consanguineous marriages.
This is a collaborative study from the ophthalmology and gastroenterology departments of a tertia... more This is a collaborative study from the ophthalmology and gastroenterology departments of a tertiary care hospital, designed to investigate the ocular features in patients with autoimmune liver disease (ALD). Seventy-two eyes of 36 patients with ALD, and 40 eyes of 20 controls with normal ocular findings were evaluated. Schirmer test, tear film break-up time, pachymetry, macular thickness with optic coherence tomography, and optic nerve head analysis with the HRT III were performed in addition to complete ophthalmologic examination. Of the 36 patients, 31 were female (86.1%) and 5 were male (13.9%). The average age of patients was 47.7 ± 13.3 years (21-76 years). Autoimmune hepatitis in 22 patients (61.1%), primary biliary cirrhosis in 10 patients (27.8%), and primary sclerosing cholangitis in 4 patients (11.1%) were detected as etiologic causes. Cataract was seen more often in the study group. Tear film break-up time and Schirmer test results were significantly lower in the study group than in the controls. Other parameters were not different from control group. ALD showed a marked preponderance of females, with sex ratios of 6 females per male supportive to literature. The basal tear secretion and tear film stability are lower, and the dry eye symptoms are more common among the cases with ALD.
A 36-year-old woman with no prior medical history presented with a unilateral decrease in vision ... more A 36-year-old woman with no prior medical history presented with a unilateral decrease in vision and iridocyclitis to our hospital. External examination demonstrated multifocal, firm, elevated, non-tender skin nodules on the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s face and left hand. In addition, slit-lamp biomicroscopy revealed gray, cheesy-appearing nodules on the iris surface of the affected eye. Anterior chamber paracentesis and pars plana vitrectomy did not reveal further information. Skin nodule biopsy, however, demonstrated multiple fragmented organisms within histiocytes, consistent with leprosy. The iridocyclitis resolved after treatment with dapsone, corticosteroids, and rifampin and her vision returned to 20/20.
Journal of American Association for Pediatric Ophthalmology and Strabismus, 2009
To investigate the demographic characteristics and ocular features of patients with childhood-ons... more To investigate the demographic characteristics and ocular features of patients with childhood-onset Behçet disease. Patients for this retrospective study were selected using the data obtained from medical records of 34 patients with childhood-onset Behçet disease being followed up in the Uveitis Department of Ankara Ulucanlar Eye Education and Research Hospital between January 2003 and May 2008. Of 34 patients, 24 were boys (70.5%) and 10 were girls (29.4%). The average age of patients was 14.5 +/- 1.9 years (range, 10-16 years). Mean follow-up period was 4.5 +/- 2 years (range, 2-10 years). During the follow-up, panuveitis, posterior uveitis, and anterior uveitis were diagnosed in 18 (52.9%), 11 (32.3%), and 5 (14.7%) patients, respectively. Ocular findings included cataract in 20 patients (58.8%), posterior synechiae in 8 (23.5%), posterior capsular opacification secondary to cataract surgery in 8 (23.5%), vitreous condensation due to previous episodes of vitritis in 17 (50%), optic atrophy in 10 (29.4%), cystoid macular edema in 5 patients (14.7%), narrowed and occluded retinal vessels due to retinal periphlebitis and branched retinal vein occlusion in 2 (5.8%), neovascularization of the disk in 1 (2.9%), and phthisis bulbi in 1 patient (2.9%). Based on the results that were obtained in this series, panuveitis was the most common type of uveitis in cases with childhood-onset Behçet disease. Cataract was the most common anterior segment complication. Optic atrophy was the most common posterior segment complication. Male predominance was determined in this study.
Journal of American Association for Pediatric Ophthalmology and Strabismus, 2008
To compare the prevalence of refractive errors in patients with headache and a control population... more To compare the prevalence of refractive errors in patients with headache and a control population. Three hundred ten patients with headache and 843 controls were retrospectively evaluated. Complete ophthalmologic examination was performed in the headache group. Autorefraction was performed in all participants (with cycloplegia under 10 years of age). Myopia was defined as the spherical equivalent refraction of at least -0.50 D, hyperopia as the spherical equivalent refraction of at least +2.0 D, and astigmatism as the cylinder of at least 1.0 D. Main outcome measures were refractive error, anisometropia, and previous miscorrection of refractive error. Chi-square and Student&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s t-tests were used for statistical analysis. Total prevalence of refractive errors was higher in the headache group (p = 0.002). The rate of astigmatism was higher in the headache group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001), while that of myopia and hyperopia were similar in both groups (p = 0.74, p = 0.79, respectively). The rates of compound and mixed astigmatism were higher in the headache group (p = 0.026, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively). The rates of anisometropia and previous miscorrection of refractive error were higher in the headache group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001 for both). Children with headache have a statistically significant increased risk of total refractive errors (OR = 1.57, 95% CI: 1.18-2.07), anisometropia (OR = 9.59, 95% CI: 5.72-16.1), and miscorrection of refractive error (OR = 9.57, 95% CI: 5.43-16.9). Compound and mixed types of astigmatism, anisometropia, and miscorrection of refractive error were found more often in patients with headache than in control subjects.
To investigate changes in corneal shape and anterior segment following retinal detachment surgery... more To investigate changes in corneal shape and anterior segment following retinal detachment surgery. 25 consecutive patients with retinal detachment were enrolled in this study. Computer-assisted videokeratography was performed before and after retinal detachment surgery and changes in the anterior segments of postoperative patients were also noted. In the local buckling group, statistically significant changes were observed in the anterior chamber depth, lens thickness, and vitreous length (distance from posterior surface of lens to the retina) in the postoperative period. However, in the encircling group, statistically meaningful changes were observed in the vitreous length, axial length of the globe, and the central corneal curvature and thickness in the postoperative period. Corneal topography and axial measurements may be useful for evaluating the shape of the cornea after retinal detachment surgery. Because the resultant refractive changes are very important for the visual rehabilitation of the patients.
International journal of clinical and experimental medicine, 2015
The aim of this study is to assess clinical outcomes of 23-gauge vitrectomy and silicone oil (SO)... more The aim of this study is to assess clinical outcomes of 23-gauge vitrectomy and silicone oil (SO) tamponade combined with and without phacoemulsification (PE) in rhegmatogenous retinal detachment (RRD). The study included forty eyes of 40 patients that underwent 23-gauge vitrectomy and SO tamponade combined with and without PE. Twenty eyes of 20 cases, of whom underwent 23-gauge vitrectomy and SO tamponade combined with PE were allocated to the group 1. Likewise, 20 eyes of 20 cases that underwent 23-gauge vitrectomy and SO tamponade alone were allocated to the group 2. Best corrected visual acuity (BCVA) between two groups was compared. There was no significant difference in BCVA between the two groups during the 6 months (P = 0.3). Recurrent retinal detachments were observed in 2 cases (10%) in both groups. There was no statistically significant difference between two groups as a point of recurrent retinal detachments (P = 1). We have found higher rates of post-vitrectomy cataract...
Purpose: To assess orbital color Doppler ultrasonography (CDU) parameters of patients with manife... more Purpose: To assess orbital color Doppler ultrasonography (CDU) parameters of patients with manifest hyperopia in comparison to the emmetropes Methods: Forty eyes of 40 patients presenting with manifest hyperopia were included into the study. Forty eyes of 40 emmetropes healthy volunteers also were examined as the control group. We have evaluated ophthalmic artery (OA), central retinal artery (CRA), posterior ciliary artery, central retinal vein (CRV), and superior ophthalmic vein (SOV) flow velocities and resistance indices (RI). Results: RI value in the OA and mean velocities (MV) in the SOV were significantly higher in the group of manifest hyperopia. CDU parameters of the CRA, CRV, nasal and temporal posterior ciliary artery (nPCA, tPCA)) between hyperopic group and the control group were statistically insignificant. Conclusion: Doppler ultrasonography findings revealed that some orbital CDU parameters are altered in eyes with manifest hyperopia compared to emmetropia. Particular...
AIM: To compare the tear functions and the impression cytology scores of the patients with primar... more AIM: To compare the tear functions and the impression cytology scores of the patients with primary open angle glaucoma (POAG), ocular hypertension (OHT) and normal subjects with healthy ocular surface both functionally and clinically. METHODS: Eleven eyes of 11 patients with POAG (mean age: 62. 7 ± 6. 1y), 12 eyes of 12 patients (mean age: 62. 8 ± 6. 4y) with OHT and 12 eyes of 12 normal subjects (mean age: 62. 9 ± 6. 03y) were included to this prospective study. The patients with POAG and OHT had been recently diagnosed with these diseases and none of them had taken anti - glaucoma treatment before. In addition to conjunctival impression cytology, tear break-up time (TBUT) and basal Schirmer’s tests (BST) were performed. Impression cytology specimens of each group were graded and scored in the range of 0-3 according to Nelson’s method. Kruskal - Wallis analysis and Dunn’s multiple comparison tests were used for statistical analysis. RESULTS: The mean BST values were 10.4±1.3, 10.9±...
To examine the integrity of the ocular surfaces of subjects with and without diabetes with no con... more To examine the integrity of the ocular surfaces of subjects with and without diabetes with no conjunctival and dry eye signs and symptoms and compare conjunctival impression cytology findings in diabetics with non-proliferative and proliferative diabetic retinopathy. Conjunctival impression cytology was performed on 43 eyes of 43 subjects with non-proliferative diabetic retinopathy (NPDR), 42 eyes of 42 subjects with proliferative diabetic retinopathy (PDR), and 30 eyes of 30 control subjects. Impression cytology specimens of each group were graded and scored in the range 0-3 according to Nelson's method. There were 45 (52.9%) women and 40 (47.1%) men. The mean age of the patients was 59.6±9.3y (range, 43-76y) in NPDR group and 58.0±8.8y (range, 41-85y) in PDR group. Cases with NPDR and PDR showed statistically significant higher impression cytology scores than control group (P<0.05). There was no difference between the NPDR and PDR patients for impression cytology grading sc...
PurposeTo search subclinical platelet activation via detecting three important platelet activatio... more PurposeTo search subclinical platelet activation via detecting three important platelet activation parameters; mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in diabetic retinopathy (DR) in comparison with those in healthy adults as controls.MethodsThis prospective study included 140 patients who were followed-up at the Ankara Ulucanlar Eye Education and Research Hospital, and 40 normal subjects. All patients and control subjects underwent complete ophthalmologic evaluation. Of patients with type 2 diabetes, 43 cases with diabetes mellitus (DM) have no DR (Group 1), 45 cases with DM have nonproliferative DR (NPDR) (Group 2), and 52 cases with DM have proliferative DR (PDR) (Group 3). In addition, 40 age- and sex-matched healthy controls (Group 4) were included into the study. MPV, PDW, and PCT were measured in the studied groups.ResultsThe MPV levels were significantly altered in Group 1, Group 2, and Group 3 patients when compared with those in the controls (P&lt;0.05), whereas PDW and PCT levels were not significantly changed among groups (P&gt;0.05).ConclusionThe data provided a significant association between MPV levels and DM. Diabetic patients have increased MPV values compared with healthy subjects, but MPV levels were not altered together with the DR stage. Diabetic and DR patients have no different PDW and PCT values compared with healthy subjects. MPV may be a clue for the reflection of subclinical platelet activation in DM regardless of the DR stage.
To analyze the surgical outcomes and retinal redetachment frequency after silicone oil (SO) remov... more To analyze the surgical outcomes and retinal redetachment frequency after silicone oil (SO) removal for complex retinal detachment. This institutional-based study included 894 consecutive patients who underwent pars plana vitrectomy with SO endotamponade for complicated retinal detachment. The effects of preoperative best-corrected visual acuity, vitreous base shaving, intraoperative scleral buckling, retinectomy, SO viscosity, duration of SO, and vitreous hemorrhage at the first postoperative week on the risk of redetachment were investigated. During a mean follow-up of 39.9 months, anatomical success was not achieved in 118 patients (13.2%) after SO removal. On multivariate analysis, risk factors for recurrent retinal detachment included giant retinal tear (adjusted odds ratio [aOR], 12.39; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), high myopia (aOR, 2.70; P = 0.011), surgeries without scleral buckling (aOR, 1.97; P = 0.039), inadequate vitreous base shaving (aOR, 117.62; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), and vitreous hemorrhage at the first postoperative week (aOR, 12.13; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Retinal detachment etiology, inadequate vitreous base shaving, lack of intraoperative scleral buckling, and vitreous hemorrhage at the first postoperative week after SO removal were significant risk factors for retinal redetachment after SO removal, but preoperative visual acuity, SO viscosity, and duration of SO had no significant effect on redetachment.
to describe the demographic characteristics and ocular manifestations of patients with late-onset... more to describe the demographic characteristics and ocular manifestations of patients with late-onset Behçet disease (BD). The patients for this retrospective study were selected using the data obtained from the medical records of 16 patients with late-onset BD between January 2000 and May 2008. twelve (75%) of the cases were male and 4 (25%) were female. The mean age of patients was 53.8 ± 2.9 years (range, 51-60 years). The mean follow-up period was 4.3 ± 1.1 years (range, 3-8 years). Throughout the follow-up period, panuveitis, posterior uveitis, and anterior uveitis were detected in 11 (68.7%), 4 (25%) and 1 (6.2%) of 16 patients, respectively. in our series, the most frequent type of uveitis was panuveitis and male sex seems to be a significant risk factor for developing panuveitis. Late-onset BD showed a marked preponderance of males with a sex ratio of 3:1.
To investigate the electron microscopic findings of the anterior lens capsule in vitrectomized ey... more To investigate the electron microscopic findings of the anterior lens capsule in vitrectomized eyes with silicone oil tamponade. Ten eyes of 10 consecutive patients aged 39 to 74 years who had cataract surgery combined with silicone oil removal from December 2006 to May 2009 were included in the study. The control group included 10 patients with cataract extraction and intraocular lens implantation without history of systemic or other ocular disease. All anterior capsules underwent electron microscopic examination of the anterior lens capsule. During the capsulorhexis, the anterior lens capsule was removed. In the silicone oil tamponade group, silicone oil droplets were detected on the posterior surface of the anterior lens capsule in 5 cases (50%) and surface irregularities, pits, and depressions were present in the posterior surface of the anterior lens capsules in all cases. Silicone oil droplets may infiltrate the lens capsule, especially in diabetic patients. Surface irregularities may be associated with posterior fibrous pseudometaplasia produced by lens epithelial cells under the anterior lens capsule.
To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diab... more To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Vitreous samples were collected from 69 eyes of 69 patients with traumatic lens dislocation (n = 10), grade B PVR with rhegmatogenous retinal detachment (n = 13), grade C PVR with rhegmatogenous retinal detachment (n = 14), PDR with vitreous hemorrhage (n = 18), and PDR with vitreous hemorrhage and tractional retinal detachment (n = 14). Vitreous fluid samples were obtained at vitrectomy, and the levels of VEGF were measured by enzyme-linked immunosorbent assay. The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. Vitreous VEGF concentrations were significantly higher in the patients with grade C PVR, PDR with vitreous hemorrhage and PDR with vitreous hemorrhage and tractional retinal detachment in comparison to the control patients (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). A significant alteration was not observed in patients with grade B PVR (p = 0.55). Vitreous VEGF concentrations are increased in PDR and grade C PVR. The high VEGF concentrations could suggest a possible effect of VEGF on advanced PVR.
We investigated a healthy population of men from different regions of Turkey for the presence of ... more We investigated a healthy population of men from different regions of Turkey for the presence of congenital red-green color blindness. Using Ishihara pseudoisochromatic plates, 941 healthy men from the Turkish army were tested for congenital red-green color blindness. The prevalence of red-green color blindness was 7.33 +/- 0.98% (5.10% protans and 2.23% deutans). These ratios were higher than other reported samples from Mediterranean Europe. Higher percentages of color blindness were found in regions with a lower education level and more consanguineous marriages.
This is a collaborative study from the ophthalmology and gastroenterology departments of a tertia... more This is a collaborative study from the ophthalmology and gastroenterology departments of a tertiary care hospital, designed to investigate the ocular features in patients with autoimmune liver disease (ALD). Seventy-two eyes of 36 patients with ALD, and 40 eyes of 20 controls with normal ocular findings were evaluated. Schirmer test, tear film break-up time, pachymetry, macular thickness with optic coherence tomography, and optic nerve head analysis with the HRT III were performed in addition to complete ophthalmologic examination. Of the 36 patients, 31 were female (86.1%) and 5 were male (13.9%). The average age of patients was 47.7 ± 13.3 years (21-76 years). Autoimmune hepatitis in 22 patients (61.1%), primary biliary cirrhosis in 10 patients (27.8%), and primary sclerosing cholangitis in 4 patients (11.1%) were detected as etiologic causes. Cataract was seen more often in the study group. Tear film break-up time and Schirmer test results were significantly lower in the study group than in the controls. Other parameters were not different from control group. ALD showed a marked preponderance of females, with sex ratios of 6 females per male supportive to literature. The basal tear secretion and tear film stability are lower, and the dry eye symptoms are more common among the cases with ALD.
A 36-year-old woman with no prior medical history presented with a unilateral decrease in vision ... more A 36-year-old woman with no prior medical history presented with a unilateral decrease in vision and iridocyclitis to our hospital. External examination demonstrated multifocal, firm, elevated, non-tender skin nodules on the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s face and left hand. In addition, slit-lamp biomicroscopy revealed gray, cheesy-appearing nodules on the iris surface of the affected eye. Anterior chamber paracentesis and pars plana vitrectomy did not reveal further information. Skin nodule biopsy, however, demonstrated multiple fragmented organisms within histiocytes, consistent with leprosy. The iridocyclitis resolved after treatment with dapsone, corticosteroids, and rifampin and her vision returned to 20/20.
Journal of American Association for Pediatric Ophthalmology and Strabismus, 2009
To investigate the demographic characteristics and ocular features of patients with childhood-ons... more To investigate the demographic characteristics and ocular features of patients with childhood-onset Behçet disease. Patients for this retrospective study were selected using the data obtained from medical records of 34 patients with childhood-onset Behçet disease being followed up in the Uveitis Department of Ankara Ulucanlar Eye Education and Research Hospital between January 2003 and May 2008. Of 34 patients, 24 were boys (70.5%) and 10 were girls (29.4%). The average age of patients was 14.5 +/- 1.9 years (range, 10-16 years). Mean follow-up period was 4.5 +/- 2 years (range, 2-10 years). During the follow-up, panuveitis, posterior uveitis, and anterior uveitis were diagnosed in 18 (52.9%), 11 (32.3%), and 5 (14.7%) patients, respectively. Ocular findings included cataract in 20 patients (58.8%), posterior synechiae in 8 (23.5%), posterior capsular opacification secondary to cataract surgery in 8 (23.5%), vitreous condensation due to previous episodes of vitritis in 17 (50%), optic atrophy in 10 (29.4%), cystoid macular edema in 5 patients (14.7%), narrowed and occluded retinal vessels due to retinal periphlebitis and branched retinal vein occlusion in 2 (5.8%), neovascularization of the disk in 1 (2.9%), and phthisis bulbi in 1 patient (2.9%). Based on the results that were obtained in this series, panuveitis was the most common type of uveitis in cases with childhood-onset Behçet disease. Cataract was the most common anterior segment complication. Optic atrophy was the most common posterior segment complication. Male predominance was determined in this study.
Journal of American Association for Pediatric Ophthalmology and Strabismus, 2008
To compare the prevalence of refractive errors in patients with headache and a control population... more To compare the prevalence of refractive errors in patients with headache and a control population. Three hundred ten patients with headache and 843 controls were retrospectively evaluated. Complete ophthalmologic examination was performed in the headache group. Autorefraction was performed in all participants (with cycloplegia under 10 years of age). Myopia was defined as the spherical equivalent refraction of at least -0.50 D, hyperopia as the spherical equivalent refraction of at least +2.0 D, and astigmatism as the cylinder of at least 1.0 D. Main outcome measures were refractive error, anisometropia, and previous miscorrection of refractive error. Chi-square and Student&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s t-tests were used for statistical analysis. Total prevalence of refractive errors was higher in the headache group (p = 0.002). The rate of astigmatism was higher in the headache group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001), while that of myopia and hyperopia were similar in both groups (p = 0.74, p = 0.79, respectively). The rates of compound and mixed astigmatism were higher in the headache group (p = 0.026, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively). The rates of anisometropia and previous miscorrection of refractive error were higher in the headache group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001 for both). Children with headache have a statistically significant increased risk of total refractive errors (OR = 1.57, 95% CI: 1.18-2.07), anisometropia (OR = 9.59, 95% CI: 5.72-16.1), and miscorrection of refractive error (OR = 9.57, 95% CI: 5.43-16.9). Compound and mixed types of astigmatism, anisometropia, and miscorrection of refractive error were found more often in patients with headache than in control subjects.
To investigate changes in corneal shape and anterior segment following retinal detachment surgery... more To investigate changes in corneal shape and anterior segment following retinal detachment surgery. 25 consecutive patients with retinal detachment were enrolled in this study. Computer-assisted videokeratography was performed before and after retinal detachment surgery and changes in the anterior segments of postoperative patients were also noted. In the local buckling group, statistically significant changes were observed in the anterior chamber depth, lens thickness, and vitreous length (distance from posterior surface of lens to the retina) in the postoperative period. However, in the encircling group, statistically meaningful changes were observed in the vitreous length, axial length of the globe, and the central corneal curvature and thickness in the postoperative period. Corneal topography and axial measurements may be useful for evaluating the shape of the cornea after retinal detachment surgery. Because the resultant refractive changes are very important for the visual rehabilitation of the patients.
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