Papers by Chittaranjan Routray
Indian Journal of Natural Sciences, 2020
NH2PAMAM based dendrimer complex has been developed andthe extended release of Cyclophosphamide (... more NH2PAMAM based dendrimer complex has been developed andthe extended release of Cyclophosphamide (CYC) was investigated by changing formulation variables. The dendrimer hydrogels so formed were characterized by FTIR, Thermogrametry Analysis (TGA) and Scanning Electron Microscopy (SEM).The equilibrium swelling indicated the distinct sensitiveness of the matrix to pH value and temperature.Within 10 h the cumulative release amount of CYC-loaded in the matrix was about 84% and 86% at pH 7.4 and 3.4 respectively. The Controlled Drug delivery of CS/PCL-G-NH2PAMAM was studied using broad spectrum anticancer drug Cycloposphamide. The most conspicuous part of the present study lies in the population of various kinetic models for drug delivery systems. A simple kinetic method has been used to monitor drug delivery kinetics. The various kinetic parameters like k and n value have been computed and the mechanism of invitro drug release of the model drugs have been postulated. The complex developed so far are useful as carriers in drug delivery systems. These complexes can be used as antibacterial agents in pharmaceutical and other medical applications.
INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH IN TECHNOLOGY, 2018
The structural modification of organic molecules has considerable biological relevance and coordi... more The structural modification of organic molecules has considerable biological relevance and coordination of these compounds to metal ions significantly alters their biological activity. With this views , some S chiff base ligands are synthesized by the condensation of unsub/sub. aminothiazole with salicyl/napthyl aldehyde and their metal complexes with trasition metals. Cu(II),Ni(II),Zn(II) and Co(II) are prepared by adopting earlier procedure1. The complexes are characterized by elemental analysis, spectral study as well as by magnetic moment measurement. The structural elucidation of the molecules is based on electronic, IR, NMR as well as Magnetic S usceptibility measurement. The data are indicative of the fact that metal is bonded to ligand through phenolic oxygen and imino nitrogen atom. The anti-microbial assay of the prepared samples are carried out by adopting modern protocol and found to be good antibacterial and antifungal agents2.
International Journal of All Research Education and Scientific Methods, 2021
In this work attempts have been made to prepare zinc oxide coated/modified with cellulose acetate... more In this work attempts have been made to prepare zinc oxide coated/modified with cellulose acetate films or cotton fibers in order to improve the property of the fibers/films. Cotton and cellulose acetate being the most abundant, biodegradable, biocompatible,low cost biopolymers have been used. The synthesis of zinc oxide nano particle modified cellulose acetate and cotton fabrics is performed by in situ precipitation methods and analysis of the multifunctional properties, such as photocatalytic cleaning and hydrophobicity is performed. The most common cheaper method of synthesis i.e. the in situ growth of the ZnO nanoparticles on cellulose acetate and cotton fabrics separately performed by dip coat sono chemical and homogeneous stirring respectively is presented emphasizing the concentration, shape and size of the ZnO NPs. The morphology of surface is characterized by SEM and more roughness was observed in modified surfaces due to presence of ZnO NPs and wax . The photocatalytic cleaning are analysed experimentally and the modified fiber and film have better value compared to unmodified one. The hydrophobic nature was analysed by the liquid contact angle measurement method and the modified cotton showed a contact angle of 125.50 and 69.80.The porosity of ZnO NPs modified surfaces also decreased compared to unmodified fibers and films , hence proving better hydrophobicity.XRD data revels the wurzite structure of the coated ZnO NPs and improved crystallinity after modification.
Indian Journal of Natural Sciences, 2020
Bio degradable polymeric film is made out of banana peels taking starch along with glycerol as a ... more Bio degradable polymeric film is made out of banana peels taking starch along with glycerol as a plasticizer and turmeric as an antioxidant so as to prevent any antimicrobial activity by blending all together. The mechanical properties such as tensile strength, young’s modulus, break point elongation of the dried film was analyzed by tensile tester (Colorcon). Biodegradability of the prepared film was also tested by soil burial method and the morphology of the degradable film was examined by SEM. Also the porosity of the film was measured by water dipping method. The developed film is biodegradable and a suitable alternative for packaging .Also will somewhat help in reducing the pollution caused by plastics.
Keywords: Biodegradable, Banana Peel, Tensile Strength, porosity, packaging
Sodhasanchar Bulletin, 2020
Copper in industrial waste water is a major environment concern .Bio adsorption is a recent eco-f... more Copper in industrial waste water is a major environment concern .Bio adsorption is a recent eco-friendly technique that gained importance in this decade to remove these toxic metal ions from industrial effluents and make it fit for human use. The present study investigates the successfully use of eco-friendly adsorbents banana peels and orange peels those are discarded as fruit waste. So this study intends to seek out potential of orange and banana peels to act as water purification due to their low cost and since they don't need to be chemically modified .Orange and Banana peels are collected and dried, then grained and sieved. The sieved peel particles are added into waste water collected from industries. The heavy metal concentration in sample water before and after treatment with the fruit peels were analyzed in XRF and the result showed that orange and banana peels effectively removed Mn,Fe,Zn,Ti,Sn from waste water and the % adsorption increased with increase in concentration of the peel powder. The percentage of removal of Mn,Fe,Zn,Ti,Sn from Industrial waste water by using orange peels at 4gm/100 ml was 95.04,98.44, 100, 100, 100 where as by using banana peel the percentage of adsorption of the same metals were 100, 97.85, 100, 100, 47.23.So owing to the result it suggests that in near future banana and orange peels can act as an effective adsorbent materials for removal metals or metal ions from industrial sewage systems.
Mukt Shabd Journal, 2020
D-Limonene essential oil was extracted from orange peels by soxhlation method using different sol... more D-Limonene essential oil was extracted from orange peels by soxhlation method using different solvents like ethanol, methanol, n-hexane, 1-propanol and distilled water in order to compare the yield percentage. The percentage of yield was in the order of ethanol > 1- propanol>hexane > distilled water>methanol. The study on variation of percentage yield with
extraction time and weight of the peels showed a linear trend. The extracted oils were characterized by UV-Visible, FT-IR and 1H NMR analysis.
Key words: D-Limonene, soxhlation, UV-Visible, FT-IR , 1H NMR
Applied Science and Advanced Materials International, 2015
The graft copolymerization of methyl methacrylate (MMA), acrylic acid (AA) and acrylonitrile (AN)... more The graft copolymerization of methyl methacrylate (MMA), acrylic acid (AA) and acrylonitrile (AN) onto cellulose acetate (CA) was carried out homogeneously in different solvents like N,N-dimethyl acetamide (DMAc), dimethyl sulfoxide (DMSO), 1,4-dioxane and acetone taking benzoyl peroxide (BPO), ceric ammonium nitrate (CAN) and tin (II) 2-ethyl hexanoate [Sn(Oct) 2 ] as catalysts. The molecular weight of the grafted homopolymer was evaluated as a function of reaction time and temperature, amount of initiator and monomer. The grafted products were characterized by infrared spectroscopy. Thermal decomposition of the optimized grafted products of CA was studied using thermo-gravimetric analysis (TG), differential thermo-gravimetry (DTG) at four heating rates, 5, 10, 20 and 30 °C and also by differential scanning calorimetry (DSC). Almost all the thermograms showed three major decomposition steps and the kinetic parameters for the three decomposition steps were estimated with the help of Coats and Redfern method.
Indian Journal of Natural Sciences, 2020
Synthesis of graphene oxide and reduced graphene oxide from low cost coal and ecofriendly reducti... more Synthesis of graphene oxide and reduced graphene oxide from low cost coal and ecofriendly reduction process has been synthesized from powdered coal by modified hammer's method and reduced by treating with black tea extract at 90 0 C for 2 hrs. The graphene oxide(GO) and reduced graphene oxide(RGO) so obtained were characterized by UV, FT-IR, XRD, Raman and SEM.
Indian Journal of Natural Sciences, 2020
Graphite electrodes so obtained from waste zinc-carbon batteries were washed several times with w... more Graphite electrodes so obtained from waste zinc-carbon batteries were washed several times with water to remove impurities and made into powder and then treated with mixture of HCl and HNO3(3:1)followed by drying at 600C to get pure graphite powder that was used as a starting material to synthesizegraphene oxide(GO) by improved Hammer’s method.The graphene oxide(GO) again treated with
Azadirachta indica leaf extract and converted to reduced graphene oxide(RGO).The rGO so obtained wascharacterized by UV-VIS Spectrophotometer, Fourier Transform Infrared Spectrophotometer, X-ray
Diffractometer and Scanning Electron Microscope. The characterization data gave clear evidence on effective formation of reduced graphene oxide.
Indian Journal of Natural Sciences, 2020
Ecofriendly nanocomposites have been fabricated from cellulose acetate (CA) powder with incorpora... more Ecofriendly nanocomposites have been fabricated from cellulose acetate (CA) powder with incorporation of C25A as a reinforcing material by solvent evaporation method. The consequence of Cloisite wt% on composites was evaluated by varying the composition. The morphologies of these nanocomposites were evaluated through X-ray diffraction (XRD), Scanning electron microscopy (SEM) studies. The mechanical properties of nanocomposites like hardness, tensile strength, modulus of elasticity and thermal stability showed an increasing trend with an increase of clay content from 2.5 to 10 wt %. Moreover the water retention capacity of the composites decreased considerably with increase in clay content.
Science, Technology And Development Journal, 2021
An attempt was made to obtain fabric made out of zinc oxide coating and cotton fibre with an impr... more An attempt was made to obtain fabric made out of zinc oxide coating and cotton fibre with an improved performance towards heat and wet. A cheap, biodegradable, biocompatible biopolymer i.e. cotton fabric was modified with zinc oxide nanoparticles using a cheaper in-situ deposition process and checked for multifunctional properties such as photocatalytic purity and hydrophobicity. Ultrasonic impregnation of ZnO NPs into cotton fabric structure was performed homogeneous mixing, focusing on the concentration, shape and size of ZnO NPs. The surface morphology was characterized by scanning electron microscopy. Due to the presence of ZnO NPs great roughness was observed on the modified surface. Photocatalytic cleaning has been verified by putting a stain of turmeric or tea on the modified fiber and exposing it to sunlight. The hydrophobicity is analyzed by measuring the contact angle of the liquid, and the contact angles of the modified cotton is 125.50. XRD data shows the wurtzite structure of the coated ZnO nanoparticles and the improved crystallinity after modification.UV-Visible analysis proved the presence of ZnO NPs in cotton or cellulose structure and by TGA study the improved thermal stability of the modified fiber was
confirmed.
Keywords: ZnONP, hydrophobicity, SEM, XRD,UV-VIS,TGA.
African Journal of Biological Sciences, 2024
This study focuses on the development and comprehensive evaluation of a sustained release matrix ... more This study focuses on the development and comprehensive evaluation of a sustained release matrix system for metformin hydrochloride, a widely prescribed antidiabetic drug, using hydroxypropyl methylcellulose (HPMC) as the release-controlling polymer. The research aimed to optimize a once-daily formulation to enhance patient compliance and therapeutic efficacy in the management of type 2 diabetes mellitus. Various formulations were prepared using different ratios of drug to HPMC (1:0.5, 1:1, 1:1.5, and 1:2) via direct compression method. The optimized formulation (F3, drug:HPMC ratio 1:1.5) was extensively characterized for physicochemical properties, in vitro release profile, and stability under accelerated conditions. Physicochemical characterization, including FTIR spectroscopy and DSC analysis, confirmed the absence of significant drug-polymer interactions. The optimized formulation exhibited desirable swelling behaviour and mechanical strength. In vitro dissolution studies revealed a controlled release profile, with approximately 95.7% of the drug released over 24 hours, following Higuchi kinetics (r² = 0.9924). Stability studies conducted over six months under accelerated conditions (40±2°C, 75±5% RH) demonstrated that the formulation maintained its physical, chemical, and dissolution characteristics, with an f2 similarity factor of 68.5 between initial and 6-month dissolution profiles. This research provides a promising foundation for a once-daily metformin hydrochloride formulation, potentially offering improved patient compliance and therapeutic outcomes in type 2 diabetes management. The study underscores the effectiveness of HPMC-based matrix systems in achieving sustained drug release and highlights the need for further in vivo investigations to establish bioequivalence and clinical efficacy.
Chemical Physics Impact, 2023
Herein, a cost-effective and nontoxic method was employed for the synthesis of g-C3N4-FeVO4 heter... more Herein, a cost-effective and nontoxic method was employed for the synthesis of g-C3N4-FeVO4 heterojunction nanocomposite photocatalyst. In this method, first g-C3N4 was synthesized from urea by chemical free thermal treatment method. Then FeVO4 nanomaterial was introduced on its surface by co-precipitation method. The
prepared nanocomposite was characterized by XRD, Raman, FTIR, XPS, FESEM, and UV-DRS to determine the crystalline phase, functionality, bonding, morphology and band gap. The synthesized nanomaterial was used for the photocatalytic degradation of highly carcinogenic rhodamine B (Rh B) dye from aqueous solution using solarlight
irradiation. The composite has remarkably higher photocatalytic behavior compared to pure g-C3N4 and FeVO4. Again, the degradation rate constant of Rh B for g-C3N4-FeVO4 is remarkably more compare to its parent materials. The pattern of the heterojunction formation between g-C3N4 and FeVO4 helps to separate the electron
pair thereby increased the photoactivity properties of the composite. Scavenger studies were also performed in order to understand the mechanism of photodegradation. It was observed that along with the electron and hole
pairs generated by light photons, hydroxide radicals play an important role in the degradation mechanism
International Journal of Botany Studies, 2020
2019 Novel corona-virus (2019-nCoV) is considered to be a global risk and put the entire globe in... more 2019 Novel corona-virus (2019-nCoV) is considered to be a global risk and put the entire globe into unrest. Specific drug against the virus is unavailable. This tricky situation requires development of pharmacophores for efficient treatment against severe acute 2019-nCoV. The crystal structure of SARS-CoV-2 main protease (Mpro) has been released, thus can be used for fast in silico molecular docking. This may result into identification of active bio-molecules principally phytochemicals. In silico molecular docking revealed that the phytochemical, Ferulic acid effectively binds at the active pocket of the SARSCoV- 2 main protease
Keywords: 2019-nCoV, SARS-CoV-2, SARS-CoV-2 main protease, Molecular docking, Ferulic acid.
CA-g-PMMA copolymer has been synthesized in homogeneous medium of dimethyl sulfoxide (DMSO) using... more CA-g-PMMA copolymer has been synthesized in homogeneous medium of dimethyl sulfoxide (DMSO) using ceric ammonium nitrate (CAN) as initiator. Different grafting parameters, such as graft yield, grafting efficiency and total conversion of monomer to polymer are evaluated at different reaction conditions of temperature, time, monomer and initiator concentrations. It is observed that the graft yield decreases with increase in temperature of grafting. CAN in presence of DMSO forms free radical on cellulose acetate (CA) backbone via ring opening mechanism and polymethyl methacrylate (PMMA) is grafted through homogeneous breaking of the acrylic double bond. The role of methylene blue (MB) as a homopolymer inhibitor and its effect on grafting is also studied. In presence of MB the amount of PMMA homopolymer formation reduces and consequently graft yield increases. The viscosity average molecular weights of grafted PMMA and rate of grafting are also calculated. The products are characterized...
Poly (methyl methacrylate) (PMMA) is successfully grafted onto cellulose in homogeneous medium in... more Poly (methyl methacrylate) (PMMA) is successfully grafted onto cellulose in homogeneous medium in N,N-dimethyl acetamide/LiCl solvent system. The method is based upon ring opening reaction of cellulose with Ce ion. Ceric ammonium nitrate (CAN) forms free radical on cellulose back bone in presence of DMSO via ring opening mechanism and PMMA is grafted through homogeneous breaking of the acrylic double bond. Methylene blue was used as an inhibitor to check the formation of homopolymer. The graft yield and grafting efficiency was studied by varying reaction time, temperature, and monomer concentration. The products are characterized by FTIR and H-NMR analysis and a possible reaction mechanism is deduced. Thermal degradation of the grafted products is also studied by thermo-gravimetric analysis (TG).
World Academy of Science, Engineering and Technology, International Journal of Chemical, Molecular, Nuclear, Materials and Metallurgical Engineering, 2013
Homogeneous graft copolymerization of methyl methacrylate (MMA) onto cellulose was carried out in... more Homogeneous graft copolymerization of methyl methacrylate (MMA) onto cellulose was carried out in N, N – dimethyl acetamide/LiCl (DMAc/LiCl) and dimethyl sulfoxide/ paraformaldehyde (DMSO/PF) solvent system taking ceric ammonium nitrate (CAN), benzoyl peroxide (BPO) and tin (II)-2ethyl hexanoate [Sn(Oct)2] as initiators. Different grafting parameters like graft yield (GY), grafting efficiency (GE) and total conversion of monomer to polymer (TC) were evaluated at different reaction conditions of temperature, time, and variation of the amount of monomer and initiator. The viscosity average molecular weight of grafted PMMA and number of grafts per cellulose chain were also calculated. The products were characterized by FT-IR and 1H-NMR analyses and possible reaction mechanisms were deduced. Thermal degradation of the grafted products was also studied by thermogravimetric analysis (TG) and differential thermo-gravimetry (DTG). Keywords—Grafting, grafting efficiency, homogeneous medium, ...
Cellulose acetate-g-polymethyl methacrylate (CA-g-PMMA) copolymer was synthesized in homogeneous ... more Cellulose acetate-g-polymethyl methacrylate (CA-g-PMMA) copolymer was synthesized in homogeneous medium, taking dimethyl sulfoxide (DMSO), 1,4-dioxane, N,N-dimethyl acetamide (DMAc) and acetone as solvents and ceric ammonium nitrate (CAN), benzoyl peroxide (BPO) and tin(II) 2-ethyl hexanoate [Sn(Oct) 2 ] as initiator. The effects of solvents and initiators on graft yield (GY) and grafting efficiency (GE) were studied. The viscosity average molecular weight of grafted PMMA was calculated. The role of methylene blue (MB) as a homopolymer inhibitor and its effect on grafting was also studied. In the presence of MB the molecular weight of the grafted PMMA reduced and consequently grafting efficiency and the number of grafts per polymer chain increased. The products were characterized by FTIR and 1 H-NMR analyses and possible reaction mechanisms for different initiators were deduced. The thermal degradation of the grafted products was also studied by thermogravimetric analysis (TG) and d...
This research gives a brief discussion on work done in the formation of bioethanol from rice stra... more This research gives a brief discussion on work done in the formation of bioethanol from rice straws using physical and chemical methods. The physical methods include washing, air air drying, cutting, autoclave. The rice straws are cut into fine pieces and washed thoroughly under tap water and then air dried. The chemical methods include pre-treatment and fermentation. The pretreatment is basically done in order to extract the reducing sugarfrom the lignin components of the rice straws by cellulase enzyme obtained from fungus grown over breads. The pre-treatment is done for about 48 hoursunder room temperature. The fermentation is done with the help of yeast (Saccharomyces Cerevisiae) in order to extract ethanol from the pre-treated solution.The extracted ethanol was characterized by FT-IR and H NMR analysis. The bioconversion offers a cheap and safe method of disposing agricultural waste and conversion of lignocellulose into ethanol.
Cellulose acetate-g-polymethyl methacrylate (CA-g-PMMA) copolymer was synthesized in homogeneous ... more Cellulose acetate-g-polymethyl methacrylate (CA-g-PMMA) copolymer was synthesized in homogeneous medium, taking dimethyl sulfoxide (DMSO), 1,4-dioxane, N,N-dimethyl acetamide (DMAc) and acetone as solvents and ceric ammonium nitrate (CAN), benzoyl peroxide (BPO) and tin(II) 2-ethyl hexanoate [Sn(Oct)2] as initiator. The effects of solvents and initiators on graft yield (GY) and grafting efficiency (GE) were studied. The viscosity average molecular weight of grafted PMMA was calculated. The role of methylene blue (MB) as a homopolymer inhibitor and its effect on grafting was also studied. In the presence of MB the molecular weight of the grafted PMMA reduced and consequently grafting efficiency and the number of grafts per polymer chain increased. The products were characterized by FTIR and H-NMR analyses and possible reaction mechanisms for different initiators were deduced. The thermal degradation of the grafted products was also studied by thermogravimetric analysis (TG) and diffe...
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Papers by Chittaranjan Routray
Keywords: Biodegradable, Banana Peel, Tensile Strength, porosity, packaging
extraction time and weight of the peels showed a linear trend. The extracted oils were characterized by UV-Visible, FT-IR and 1H NMR analysis.
Key words: D-Limonene, soxhlation, UV-Visible, FT-IR , 1H NMR
Azadirachta indica leaf extract and converted to reduced graphene oxide(RGO).The rGO so obtained wascharacterized by UV-VIS Spectrophotometer, Fourier Transform Infrared Spectrophotometer, X-ray
Diffractometer and Scanning Electron Microscope. The characterization data gave clear evidence on effective formation of reduced graphene oxide.
confirmed.
Keywords: ZnONP, hydrophobicity, SEM, XRD,UV-VIS,TGA.
prepared nanocomposite was characterized by XRD, Raman, FTIR, XPS, FESEM, and UV-DRS to determine the crystalline phase, functionality, bonding, morphology and band gap. The synthesized nanomaterial was used for the photocatalytic degradation of highly carcinogenic rhodamine B (Rh B) dye from aqueous solution using solarlight
irradiation. The composite has remarkably higher photocatalytic behavior compared to pure g-C3N4 and FeVO4. Again, the degradation rate constant of Rh B for g-C3N4-FeVO4 is remarkably more compare to its parent materials. The pattern of the heterojunction formation between g-C3N4 and FeVO4 helps to separate the electron
pair thereby increased the photoactivity properties of the composite. Scavenger studies were also performed in order to understand the mechanism of photodegradation. It was observed that along with the electron and hole
pairs generated by light photons, hydroxide radicals play an important role in the degradation mechanism
Keywords: 2019-nCoV, SARS-CoV-2, SARS-CoV-2 main protease, Molecular docking, Ferulic acid.
Keywords: Biodegradable, Banana Peel, Tensile Strength, porosity, packaging
extraction time and weight of the peels showed a linear trend. The extracted oils were characterized by UV-Visible, FT-IR and 1H NMR analysis.
Key words: D-Limonene, soxhlation, UV-Visible, FT-IR , 1H NMR
Azadirachta indica leaf extract and converted to reduced graphene oxide(RGO).The rGO so obtained wascharacterized by UV-VIS Spectrophotometer, Fourier Transform Infrared Spectrophotometer, X-ray
Diffractometer and Scanning Electron Microscope. The characterization data gave clear evidence on effective formation of reduced graphene oxide.
confirmed.
Keywords: ZnONP, hydrophobicity, SEM, XRD,UV-VIS,TGA.
prepared nanocomposite was characterized by XRD, Raman, FTIR, XPS, FESEM, and UV-DRS to determine the crystalline phase, functionality, bonding, morphology and band gap. The synthesized nanomaterial was used for the photocatalytic degradation of highly carcinogenic rhodamine B (Rh B) dye from aqueous solution using solarlight
irradiation. The composite has remarkably higher photocatalytic behavior compared to pure g-C3N4 and FeVO4. Again, the degradation rate constant of Rh B for g-C3N4-FeVO4 is remarkably more compare to its parent materials. The pattern of the heterojunction formation between g-C3N4 and FeVO4 helps to separate the electron
pair thereby increased the photoactivity properties of the composite. Scavenger studies were also performed in order to understand the mechanism of photodegradation. It was observed that along with the electron and hole
pairs generated by light photons, hydroxide radicals play an important role in the degradation mechanism
Keywords: 2019-nCoV, SARS-CoV-2, SARS-CoV-2 main protease, Molecular docking, Ferulic acid.