RAC1
Rac1 (RAS-related C3 botulinus toxin substrate 1) は、ヒト細胞に存在するタンパク質であり、RAC1遺伝子によりコードされている[5][6]。RAC1は選択的スプライシングにより異なる機能を持ったいくつかのタンパク質を生成しており、このうちの1つがRac1である[7]。
Rac1は、悪性黒色腫[8][9][10]や肺非小細胞癌[11] を含むさまざまな癌の発生において、重要な役割を果たしていると考えられている。そのため、現在これらの疾患に対する治療標的と考えられている[12]。
機能
[編集]低分子量GTPアーゼの1つであるうえ、RhoファミリーGタンパク質であるRacサブファミリーのメンバーでもある。このスーパーファミリーのメンバーは、細胞の増殖や細胞骨格の再構築、プロテインキナーゼの活性化などさまざまな細胞における事象を制御している[13]。
Rac1は、細胞周期や細胞接着、(アクチンネットワークを介した)細胞運動、上皮細胞における悪性形質転換(上皮幹細胞維持における必要物質であると考えられている)などを含む多くの細胞プロセスにおける、多方面的な制御因子である。
相互作用
[編集]ARFIP2[14][15][16]、Myotonic dystrophy protein kinase[17]、T-cell lymphoma invasion and metastasis-inducing protein 1[18][19]、PARD6B[20]、PAK1[21][22][23]、PAK3[14]、ARHGDIA[24][25][26][27][28][29]、Myd88[30]、PARD6A,[20][31]、STAT3[32]、IQGAP2[33]、NCKAP1[34]、IQGAP1[23][35][36][37]、FHOD1[38]、BAIAP2[39]、RICS[40][41]、FMNL1[42]などのタンパク質と相互作用することが明らかにされている。
脚注
[編集]- ^ a b c GRCh38: Ensembl release 89: ENSG00000136238 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001847 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ Worthylake, D K; Rossman K L, Sondek J (Dec. 2000). “Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1”. Nature (England) 408 (6813): 682–8. doi:10.1038/35047014. ISSN 0028-0836. PMID 11130063.
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- ^ Brill, S; Li S, Lyman C W, Church D M, Wasmuth J J, Weissbach L, Bernards A, Snijders A J (September 1996). “The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases”. Mol. Cell. Biol. (UNITED STATES) 16 (9): 4869–78. ISSN 0270-7306. PMC 231489. PMID 8756646 .
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- ^ Fukata, Masaki; Watanabe Takashi, Noritake Jun, Nakagawa Masato, Yamaga Masaki, Kuroda Shinya, Matsuura Yoshiharu, Iwamatsu Akihiro, Perez Franck, Kaibuchi Kozo (June 2002). “Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170”. Cell (United States) 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. ISSN 0092-8674. PMID 12110184.
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- ^ Westendorf, J J (Dec. 2001). “The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element”. J. Biol. Chem. (United States) 276 (49): 46453–9. doi:10.1074/jbc.M105162200. ISSN 0021-9258. PMID 11590143.
- ^ Miki, H; Yamaguchi H, Suetsugu S, Takenawa T (Dec. 2000). “IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling”. Nature (England) 408 (6813): 732–5. doi:10.1038/35047107. ISSN 0028-0836. PMID 11130076.
- ^ Zhao, Chunmei; Ma Hong, Bossy-Wetzel Ella, Lipton Stuart A, Zhang Zhuohua, Feng Gen-Sheng (September 2003). “GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2”. J. Biol. Chem. (United States) 278 (36): 34641–53. doi:10.1074/jbc.M304594200. ISSN 0021-9258. PMID 12819203.
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推薦文献
[編集]- Benitah SA, Frye M, Glogauer M, Watt FM (2005). “Stem cell depletion through epidermal deletion of Rac1”. Science 309 (5736): 933–5. doi:10.1126/science.1113579. PMID 16081735.
- Dorseuil O, Gacon G (1997). “[Signal transduction by Rac small G proteins in phagocytes] [Signal transduction by Rac small G proteins in phagocytes]” (French). C. R. Seances Soc. Biol. Fil. 191 (2): 237–46. PMID 9255350.
- Ramakers GJ (2002). “Rho proteins, mental retardation and the cellular basis of cognition”. Trends Neurosci. 25 (4): 191–9. doi:10.1016/S0166-2236(00)02118-4. PMID 11998687.
- Esufali S, Charames S, Bapat B (2007). “Suppression of Wnt signalling leads to stabilization of Rac1 isoforms”. FEBS letters. 581 (25): 4850–4856. doi:10.1016/j.febslet.2007.09.013. PMID 17888911.
外部リンク
[編集]- rac1 GTP-Binding Protein - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス
- RAC1 Info with links in the Cell Migration Gateway