ON THE COVER
June 3, 2024
A new model, vetted by experiments on lung cancer cells, may help to explain how cancer and other diseases accumulate drug-resistance mutations that can compromise the effectiveness of treatments.
Jeff Maltas et al.
PRX Life 2, 023010 (2024)
NEW ARTICLE
A theory experimental dialogue offers new insights into the multicomponent depolymerization of actin filaments by profilin, cofilin, and twinfilin.
Ankita Arya, Sandeep Choubey, and Shashank Shekhar
PRX Life 2, 033002 (2024)
NEW ARTICLE
Experiments with synthetic droplets in cells, combined with molecular simulations, show the impact of macromolecular crowding and ATP-driven activities on condensate formation.
Tong Shu et al.
PRX Life 2, 033001 (2024)
NEW ARTICLE
Proteins at the interfaces of two immiscible condensates can act as biological switches, regulating the formation of complex architectures with shared stable interfaces.
Tianhao Li and William M. Jacobs
PRX Life 2, 023013 (2024)
NEW ARTICLE
Large and slow eukaryotic cells favor spatial over temporal comparison for chemotaxis; this study supports this heuristic notion using information theory, accounting for physical limits of sensing.
Julian Rode, Maja Novak, and Benjamin M. Friedrich
PRX Life 2, 023012 (2024)
NEW ARTICLE
Incorporating chain rigidification, desolvation, and sticker pair formation into a dynamic aging simulation explains the formation of solid shells around condensate surfaces, as observed in recent experiments.
Subhadip Biswas and Davit A. Potoyan
PRX Life 2, 023011 (2024)
NEW ARTICLE
Interactions between drug-resistant mutants and their evolutionary ancestors in the absence of treatment can significantly impact treatment efficacy. This explains pre-existing drug resistance in non-small cell lung cancer, providing new insights for treatment strategies.
Jeff Maltas et al.
PRX Life 2, 023010 (2024)
NEW ARTICLE
Social norms—the rules by which people assess others and adopt behaviors—are classified in a society where people gossip and make judgment errors independently. Key strategies that maximize cooperation and are robust against defectors are identified.
Yuma Fujimoto and Hisashi Ohtsuki
PRX Life 2, 023009 (2024)