NEW ARTICLE
Incorporating chain rigidification, desolvation, and sticker pair formation into a dynamic aging simulation explains the formation of solid shells around condensate surfaces, as observed in recent experiments.
Subhadip Biswas and Davit A. Potoyan
PRX Life 2, 023011 (2024)
NEW ARTICLE
Interactions between drug-resistant mutants and their evolutionary ancestors in the absence of treatment can significantly impact treatment efficacy. This explains pre-existing drug resistance in non-small cell lung cancer, providing new insights for treatment strategies.
Jeff Maltas et al.
PRX Life 2, 023010 (2024)
NEW ARTICLE
Social norms—the rules by which people assess others and adopt behaviors—are classified in a society where people gossip and make judgment errors independently. Key strategies that maximize cooperation and are robust against defectors are identified.
Yuma Fujimoto and Hisashi Ohtsuki
PRX Life 2, 023009 (2024)
NEW ARTICLE
A phenomenological renormalization group analysis of 3-hour spiking data from the visual cortices of urethane-anesthetized rats shows that scale invariance is intermittent, with a broad range of cortical states corresponding to small deviations around a critical point.
Daniel M. Castro et al.
PRX Life 2, 023008 (2024)
NEW ARTICLE
Even when the underlying model for a neuron is unknown, relevant information on ion channels can still be inferred by utilizing recursive piecewise assimilation of electrophysiological data, and model error can be quantified.
Stephen A. Wells, Joseph D. Taylor, Paul G. Morris, and Alain Nogaret
PRX Life 2, 023007 (2024)
NEW ARTICLE
Building on a variational quantum eigensolver and utilizing divide-and-conquer strategies, an algorithm that combines short and long DNA sequence reads shows promise for the optimization of quantum computing applied to genome assembly.
Jing-Kai Fang et al.
PRX Life 2, 023006 (2024)
NEW ARTICLE
A new spectral regularization method that disentangles entropy from coevolutionary signals in protein sequences is able to infer contact maps with higher accuracy enabling the design of new stable proteins.
Haobo Wang et al.
PRX Life 2, 023005 (2024)