07/19/2024
Short Reports
The complexity of metabolic dysfunction-associated steatohepatitis (MASH) has impaired the development of pharmacological treatments for the condition. Heejin Jun, Shanshan Liu, Jun Wu and co-workers show that nicotinic acetylcholine receptor signaling serves as an intrinsic protective mechanism against extended metabolic stress in the liver.
Image credit: pbio.3002728
Current Issue June 2024
07/18/2024
Methods and Resources
Sequencing of species that can be cultured in the laboratory results in a bias in taxon sampling. Bernard Kim, Dmitri Petrov and co-authors use cost-effective, amplification-free, low-input sequencing methods to assemble genomes of 183 single wild-collected drosophilids and inbred lines, redressing this bias towards laboratory organisms.
Image credit: pbio.3002697
07/16/2024
Research Article
RNA viruses replicate with high mutation rates, but natural selection concentrates variability in a few proteins. Beatriz Álvarez-Rodríguez, Ron Geller and colleagues measure the effect of >40,000 non-synonymous mutations across the full proteome of coxsackievirus B3, revealing significant variation in mutational tolerance within and between viral proteins, with implications for drug target selection.
Image credit: pbio.3002709
07/16/2024
Research Article
Impaired neuronal connectivity is often correlated with behavioral phenotypes in patients with autism spectrum disorders (ASD). Tsan-Ting Hsu, Yi-Ping Hsueh and co-workers link Tbr1, a causative gene of ASD, to impairments in structural and functional connectivity of the basolateral amygdala, and whole-brain synchronization, in an ASD mouse model.
Image credit: pbio.3002646
07/15/2024
Research Article
Selective attention helps humans to overcome our brain's limited processing capacity. This neuroimaging study by Huinan Hu, Gui Xue and co-authors shows how selective attention transforms memory representations to reduce interference and support long-term memory.
Image credit: pbio.3002721
07/15/2024
Research Article
Heterologous sensitization of adenylyl cyclase (AC) contributes to drug dependence. Zhong Ding, Xuechu Zhen and colleagues show that KCTD proteins 2, 5 and 17 regulate AC heterologous sensitization by enabling Cullin3 neddylation, and identifies a crucial role of this pathway in the paraventricular thalamic nucleus in regulating morphine dependence.
Image credit: pbio.3002716
07/15/2024
Essay
Aude Bernheim, Jean Cury and Enzo Poirier introduce the concept of ancestral immunity; the set of immune modules conserved between prokaryotes and eukaryotes, discussing the topology of ancestral immunity and an evolutionary scenario for its existence.
Image credit: pbio.3002717
07/08/2024
Essay
Omer Sharon, Eti Ben Simon, Matthew Walker and co-authors highlight eight of the most exciting new discoveries within sleep science, discussing how these have expanded our understanding of sleep's function at the cellular, organismal, and societal levels.
Image credit: pbio.3002684
07/01/2024
Unsolved Mystery
Mitochondria come in many shapes and sizes. Noga Preminger and Maya Schuldiner explore the diverse processes that influence mitochondrial shape and network formation, highlighting gaps in our understanding of mitochondrial architecture.
Image credit: pbio.3002671
06/11/2024
Editorial
The planetary outlook for biodiversity is dire. Leah Gerber and Gwenllian Iacona introduce a new Collection of articles that discuss the data we have and the data we need for more effective conservation policies.
Image credit: Leah Gerber
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.
July 28 - August 2
Meet Senior Editor Roli Roberts ([email protected])
September 1 - 4
Meet Associate Editor Melissa Vazquez Hernandez ([email protected])
September 9 - 11
Meet Senior Editor Ines Alvarez-Garcia ([email protected])
September 9 - 10
Meet Associate Editor Suzanne de Bruijn ([email protected])
September 24 - 28
Meet Senior Editor Ines Alvarez-Garcia ([email protected])
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